Department of Microbiology, National and Kapodistrian University of Athens, Athens, Greece.
Department of Clinical Microbiology, Tzaneio General Hospital of Piraeus, Athens, Greece.
Eur J Clin Microbiol Infect Dis. 2022 Jan;41(1):127-132. doi: 10.1007/s10096-021-04290-7. Epub 2021 Jul 15.
This study aimed to investigate the effects of a 4-year antibiotic stewardship program (ASP) in a tertiary hospital. We monitored data for 2015 (pre-intervention) and 2016-2019 (post-intervention) about antibiotic consumption (DDD/100 bed days), Clostridioides difficile infections (CDIs), resistance rates, length of stay (LOS), and annual antibiotic costs. Significant reductions were observed for total antibiotics/colistin/carbapenems/quinolones/tigecycline consumption and resistance rates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and vancomycin-resistant enterococci. Considerable reductions occurred for LOS (4.18 [2015]/3.0 [2019] days), CDIs (1.47 [2015]/0.86 [2019] per 1000 patients), antibiotic cost/patient (39.45€ [2015]/23.69€ [2019]). The ASP was successful in reducing antibiotic consumption, antibiotic costs, length of hospital stay, and CDIs.
本研究旨在探讨一项为期四年的抗生素管理计划（ASP）在一家三级医院的效果。我们监测了 2015 年（干预前）和 2016-2019 年（干预后）的抗生素使用量（DDD/100 床日）、艰难梭菌感染（CDI）、耐药率、住院时间（LOS）和年度抗生素费用的数据。观察到总抗生素/黏菌素/碳青霉烯类/喹诺酮类/替加环素的使用量和铜绿假单胞菌、肺炎克雷伯菌和耐万古霉素肠球菌的耐药率显著降低。LOS（4.18[2015]/3.0[2019]天）、CDI（1.47[2015]/0.86[2019]每 1000 例患者）和抗生素费用/患者（39.45 欧元[2015]/23.69 欧元[2019]）都有较大幅度的降低。ASP 成功地减少了抗生素的使用量、抗生素费用、住院时间和 CDI。
