血栓性血小板减少性紫癜：COVID-19 bnt162b2 疫苗接种后的新威胁
Thrombotic thrombocytopenic purpura: a new menace after COVID bnt162b2 vaccine.
机构信息
Department of Internal Medicine, Downstate Medical Center, State University of New York (SUNY), 186 Lenox Rd, Apartment 1H, NYC, Brooklyn, NY, 11226, USA.
Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan.
出版信息
Int J Hematol. 2021 Nov;114(5):626-629. doi: 10.1007/s12185-021-03190-y. Epub 2021 Jul 15.
Abstract
Thrombotic thrombocytopenic purpura (TTP) is a known menace in hematology and is quite rare in practice with known triggers. Lately, in the COVID-19 pandemic, hematology has seen a new pathology amongst which TTP associated with COVID-19 messenger RNA (mRNA) vaccine is unique. We report a case of a 69-year-old male with multiple comorbidities who presented to the hospital with severe fatigue and shortness of breath. Labs were significant for thrombocytopenia, anemia, and hemolysis with schistocytes consistent with TTP with a second dose of BNT162b2 mRNA vaccine as a likely culprit been documented.
摘要
血栓性血小板减少性紫癜（TTP）是血液学中的已知威胁，在实践中非常罕见，并有已知的诱因。最近，在 COVID-19 大流行期间，血液学出现了一种新的病理，其中与 COVID-19 信使 RNA（mRNA）疫苗相关的 TTP 较为独特。我们报告了一例 69 岁男性病例，该患者患有多种合并症，因严重疲劳和呼吸急促而到医院就诊。实验室检查显示血小板减少、贫血和溶血，伴有符合 TTP 的裂片细胞，并且记录到第二剂 BNT162b2 mRNA 疫苗可能是罪魁祸首。
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