Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim, Norway.
Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Sleep Med. 2021 Sep;85:15-20. doi: 10.1016/j.sleep.2021.06.029. Epub 2021 Jun 28.
To examine the association between subtypes of insomnia and the risk of chronic spinal pain.
The study comprised 16,401 participants without chronic spinal pain at baseline who were followed for ∼11 years. People were categorized into 'no insomnia symptoms', 'subthreshold insomnia', and 'insomnia'. Insomnia was defined according to the diagnostic classification system requiring both daytime and nighttime symptoms, and further categorized into subtypes based on nighttime symptoms (ie, sleep onset latency [SOL-insomnia], wake after sleep onset [WASO-insomnia], early morning awakening [EMA-insomnia], or combinations of these). Subthreshold insomnia comprised those with only daytime impairment or one or more nighttime symptoms. Chronic spinal pain was defined as pain in either 'neck', 'low back', or 'upper back', or a combination of these.
In multivariable regression analysis using people without insomnia as reference, people with subthreshold insomnia or insomnia had relative risks (RRs) of chronic spinal pain of 1.29 (95% confidence interval [CI] 1.21-1.38) and 1.50 (95% CI 1.34-1.68), respectively. The RRs for people with one nighttime symptom were 1.30 (95% CI 0.83-2.05) for WASO-insomnia, 1.32 (95% CI 1.06-1.65) for EMA-insomnia, and 1.70 (95% CI 1.32-2.18) for SOL-insomnia, respectively. Combinations of nighttime insomnia symptoms gave RRs from 1.45 (95% CI 1.08-1.94) for WASO + EMA-insomnia to 1.72 (95% CI 1.36-2.19) for all nighttime symptoms (SOL + WASO + EMA-insomnia).
These findings suggest that the risk of chronic spinal pain is highest among persons with insomnia subtypes characterized by sleep onset latency or among those having insomnia symptoms in all parts of the sleep period.
研究失眠亚型与慢性脊柱疼痛风险之间的关联。
本研究纳入了 16401 名基线时无慢性脊柱疼痛的参与者,随访时间约为 11 年。根据既需要日间症状又需要夜间症状的诊断分类系统,将人群分为“无失眠症状”、“亚临床失眠”和“失眠”。失眠进一步根据夜间症状分为亚型(即入睡潜伏期失眠[SOL-失眠]、睡眠后觉醒[WASO-失眠]、早醒[EMA-失眠]或这些症状的组合)。亚临床失眠包括只有日间损害或一个或多个夜间症状的人群。慢性脊柱疼痛定义为“颈部”、“下背部”或“上背部”或这些部位的组合疼痛。
在多变量回归分析中,以无失眠者为参照,亚临床失眠或失眠者发生慢性脊柱疼痛的相对风险(RR)分别为 1.29(95%置信区间[CI] 1.21-1.38)和 1.50(95%CI 1.34-1.68)。仅有一种夜间症状的 RR 分别为 WASO-失眠 1.30(95%CI 0.83-2.05)、EMA-失眠 1.32(95%CI 1.06-1.65)和 SOL-失眠 1.70(95%CI 1.32-2.18)。夜间失眠症状组合的 RR 从 WASO+EMA-失眠的 1.45(95%CI 1.08-1.94)到所有夜间症状(SOL+WASO+EMA-失眠)的 1.72(95%CI 1.36-2.19)不等。
这些发现表明,以入睡潜伏期或整个睡眠期均有失眠症状为特征的失眠亚型患者,其慢性脊柱疼痛风险最高。