二酰基甘油二辛酰甘油和油酰乙酰甘油通过抑制溶血磷脂酰转移酶来增强前列腺素的合成。
The diacylglycerols dioctanoylglycerol and oleoylacetylglycerol enhance prostaglandin synthesis by inhibition of the lysophosphatide acyltransferase.
作者信息
Goppelt-Strübe M, Pfannkuche H J, Gemsa D, Resch K
机构信息
Department of Pharmacology and Toxicology, Medical School Hannover, Federal Republic of Germany.
出版信息
Biochem J. 1987 Nov 1;247(3):773-7. doi: 10.1042/bj2470773.
Abstract
Prostanoids are synthesized by resident macrophages upon stimulation with diacylglycerols. Oleoylacetylglycerol and dioctanoylglycerol induced prostaglandin E and thromboxane synthesis in a time- and concentration-dependent manner. Both diacylglycerols inhibited the lysophosphatide acyltransferase, which is the key enzyme in the reacylation of arachidonic acid. By this mechanism the pool of free arachidonic acid available for prostanoid synthesis is increased. Both diacylglycerols were able to inhibit the membrane-bound lysophosphatide acyltransferase by a direct interaction independent of protein kinase C. Thus lysophosphatide acyltransferase could be shown to be a new target of these diacylglycerols, known as activators of protein kinase C.
摘要
前列腺素类物质是由驻留巨噬细胞在二酰基甘油刺激下合成的。油酰乙酰甘油和二辛酰甘油以时间和浓度依赖的方式诱导前列腺素E和血栓素的合成。这两种二酰基甘油均抑制溶血磷脂酰转移酶，该酶是花生四烯酸再酰化的关键酶。通过这种机制，可用于前列腺素合成的游离花生四烯酸池增加。这两种二酰基甘油都能够通过独立于蛋白激酶C的直接相互作用抑制膜结合的溶血磷脂酰转移酶。因此，溶血磷脂酰转移酶可被证明是这些二酰基甘油（已知为蛋白激酶C激活剂）的一个新靶点。
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本文引用的文献
1
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Biochem J. 1982 Apr 15;204(1):3-16. doi: 10.1042/bj2040003.
2
Control of arachidonic acid accumulation in bone marrow-derived macrophages by acyltransferases.酰基转移酶对骨髓来源巨噬细胞中花生四烯酸积累的调控
J Biol Chem. 1981 Apr 25;256(8):3690-7.
3
Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase.来自大鼠肝脏的甘油脂质酰基转移酶：1-酰基甘油磷酸酰基转移酶、1-酰基甘油磷酸胆碱酰基转移酶和二酰基甘油酰基转移酶。
Methods Enzymol. 1981;71 Pt C:528-36. doi: 10.1016/0076-6879(81)71063-2.
4
Intracellular phospholipases A.细胞内磷脂酶A
Biochim Biophys Acta. 1980 Sep 30;604(2):191-246. doi: 10.1016/0005-2736(80)90574-x.
5
Spontaneous and detergent-induced vesiculation of thymocyte plasma membranes.胸腺细胞质膜的自发和去污剂诱导的囊泡化。
Biochim Biophys Acta. 1980 Jan 25;595(2):244-56. doi: 10.1016/0005-2736(80)90087-5.
6
Characterization and subcellular localization of nucleotide cyclases in calf thymus lymphocytes.小牛胸腺淋巴细胞中核苷酸环化酶的特性及亚细胞定位
Biochim Biophys Acta. 1984 Sep 19;776(1):133-43. doi: 10.1016/0005-2736(84)90259-1.
7
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8
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J Biol Chem. 1981 Nov 25;256(22):11618-23.
9
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Biochim Biophys Acta. 1986 Mar 21;876(1):28-35. doi: 10.1016/0005-2760(86)90314-0.
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