乙醇与血液蛋白质的相互作用。
Interaction of ethanol with blood proteins.
作者信息
Stepuro I I, Artsukevich A N, Zavodnik I B, Konovalova N V, Lapshina E A
机构信息
Institute of Biochemistry, Byelorussian SSR Academy of Sciences, Grodno, USSR.
出版信息
Alcohol Alcohol Suppl. 1987;1:283-7.
PMID:3426692
Abstract
At concentrations arising in alcohol intoxication ethanol was reversibly bound to human serum albumin and hemoglobin. Alcohol altered the conformation and stability of the proteins, reduced the domain-domain interactions in the molecule of albumin and changed the binding of such hydrophobic ligands as ANS and bilirubin.
摘要
在酒精中毒时产生的浓度下，乙醇与人类血清白蛋白和血红蛋白可逆结合。酒精改变了蛋白质的构象和稳定性，减少了白蛋白分子中的结构域间相互作用，并改变了诸如ANS和胆红素等疏水配体的结合。
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