Naloxone attenuation of voluntary alcohol consumption.

The effect of naloxone on voluntary alcohol consumption was examined in two lines of rats which have recently been selectively bred for oral alcohol preference (High Alcohol Drinking or HAD line) or aversion (Low Alcohol Drinking or LAD line). Genetic differences in brain met-enkephalin content were examined in two additional lines of rats which have been genetically selected for oral alcohol preference (Alcohol-Preferring or P line) or aversion (Alcohol-Nonpreferring or NP line).