Singh Puja, Sharma Shishir, Anand Kumar, Kumar Amit, Nezam Sumaiya
Department of Periodontology and Implantology, Government of Bihar, Patna, Bihar, India.
Department of Prosthodontics and Crown and Bridge, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.
J Contemp Dent Pract. 2021 Apr 1;22(4):373-377.
To evaluate the effect of nonsurgical periodontal therapy on periodontal parameters, serum C-reactive protein (CRP) level, total leukocyte count (TLC), and differential leukocyte count (DLC) in normolipidemic patients with generalized chronic periodontitis.
A total of 60 subjects (38 males and 22 females) between 20 and 55 years of age were included in this study. Twenty subjects with generalized chronic gingivitis were assigned group I. Forty subjects with generalized chronic periodontitis were randomly divided into test groups, i.e., group II ( = 20) and control group, i.e., group III ( = 20). At baseline, clinical parameters (plaque and gingival indices, clinical attachment loss) were recorded and blood collected for lipid profile test, TLC, DLC, and CRP estimation. Patients with lipid values in the normal range continued the study. Groups I and II were provided nonsurgical periodontal therapy. Follow-up clinical examination and blood examination were done for CRP level, TLC, and DLC after 1 and 2 months.
A significant improvement in the clinical parameters was evident following scaling and root planning in group II as compared to group III. A decrease in serum CRP and TLC count was also observed, but the difference was not significant. Moreover, a reduction was observed in neutrophils, monocytes, eosinophils post therapeutically in group II but the decrease was significant only for monocyte count.
Based on the findings of the study, it can be concluded that nonsurgical periodontal therapy can reduce the inflammatory component.
Periodontal diseases comprise a wide range of inflammatory conditions affecting the supporting structures of teeth. Effect of nonsurgical periodontal therapy on chronic periodontitis can be evaluated by measuring the CRP and leukocyte concentration.
评估非手术牙周治疗对血脂正常的广泛性慢性牙周炎患者牙周参数、血清C反应蛋白（CRP）水平、白细胞总数（TLC）及白细胞分类计数（DLC）的影响。
本研究共纳入60名年龄在20至55岁之间的受试者（38名男性和22名女性）。20名患有广泛性慢性牙龈炎的受试者被分配到第一组。40名患有广泛性慢性牙周炎的受试者被随机分为试验组，即第二组（n = 20）和对照组，即第三组（n = 20）。在基线时，记录临床参数（菌斑和牙龈指数、临床附着丧失），并采集血液进行血脂检测、TLC、DLC和CRP测定。血脂值在正常范围内的患者继续进行研究。第一组和第二组接受非手术牙周治疗。在1个月和2个月后对CRP水平、TLC和DLC进行随访临床检查和血液检查。
与第三组相比，第二组在进行龈上洁治和根面平整后临床参数有显著改善。血清CRP和TLC计数也有所下降，但差异不显著。此外，第二组治疗后中性粒细胞、单核细胞、嗜酸性粒细胞数量减少，但仅单核细胞计数的减少具有显著性。
基于本研究结果，可以得出非手术牙周治疗可减轻炎症成分的结论。
牙周疾病包括一系列影响牙齿支持结构的炎症性病症。可通过测量CRP和白细胞浓度来评估非手术牙周治疗对慢性牙周炎的疗效。
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