Hu Yuxiang, Yao Yao, Xie Yumeng, Liu Qiao, He Hao, Li Zhezheng, Chen Mengjie, Zhu Lilei
Changsha Stomatological Hospital, Hunan University of Chinese Medicine, No. 389 Youyi Road, Changsha, 410004, China.
Changsha Saide Dental Clinic Co., Ltd. Changsha Furong Saide Dental Clinic, Changsha, 410001, Hunan Province, China.
BMC Oral Health. 2024 Dec 23;24(1):1545. doi: 10.1186/s12903-024-05335-x.
To investigate the association between periodontitis and inflammatory biomarkers, including systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio.
Our study comprised a cross-sectional analysis (an indirect evidence group and a periodontal health control group from January to October 2023) and a retrospective study (a direct evidence group and a non-maintenance group from January 2014 to March 2022). We analyzed demographic data, imaging measurements, and peripheral blood counts.
The study included 131 participants in the indirect evidence group, 132 in the healthy control group, 123 in the direct evidence group, and 76 in the non-maintenance group. The indirect evidence group exhibited significantly altered inflammatory biomarker levels compared to the healthy controls. Receiver operating characteristic curve analysis indicated that SII was the most effective biomarker for diagnosing periodontitis, with an area under the curve 0.758 and a Youden index 0.409. The optimal cut-off value was 437.07 × 10⁹/L, achieving a sensitivity 46.2% and a specificity 94.7%. Correlation analyses revealed significant associations between the biomarker levels and periodontitis grades, with SII showing the highest correlation coefficient (0.942). In the direct evidence group, supportive periodontal therapy significantly mitigated changes in these biomarkers.
An SII level exceeding 437.07 × 10/L could facilitate the periodontitis diagnosis and disease grade determination. SII can be utilized to assess and monitor periodontitis severity and treatment response.
研究牙周炎与炎症生物标志物之间的关联，包括全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及淋巴细胞与单核细胞比值。
我们的研究包括一项横断面分析（2023年1月至10月的间接证据组和牙周健康对照组）和一项回顾性研究（2014年1月至2022年3月的直接证据组和非维持组）。我们分析了人口统计学数据、影像学测量结果和外周血细胞计数。
该研究纳入间接证据组131名参与者、健康对照组132名、直接证据组123名和非维持组76名。与健康对照组相比，间接证据组的炎症生物标志物水平有显著变化。受试者工作特征曲线分析表明，SII是诊断牙周炎最有效的生物标志物，曲线下面积为0.758，约登指数为0.409。最佳截断值为437.07×10⁹/L，灵敏度为46.2%，特异性为94.7%。相关性分析显示生物标志物水平与牙周炎分级之间存在显著关联，SII的相关系数最高（0.942）。在直接证据组中，支持性牙周治疗显著减轻了这些生物标志物的变化。
SII水平超过437.07×10⁹/L有助于牙周炎的诊断和疾病分级的确定。SII可用于评估和监测牙周炎的严重程度及治疗反应。
