术后第 1 天血浆纤维蛋白原水平与 HBV 相关 HCC 患者行原位肝移植 2 年生存率的相关性研究。

Association of Plasma Fibrinogen Levels on Postoperative Day 1 with 2-Year Survival of Orthotopic Liver Transplantation for HBV-Related HCC.

机构信息

Department of Intensive Care Unit, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, Zhejiang, China.

出版信息

Lab Med. 2022 Jan 6;53(1):30-38. doi: 10.1093/labmed/lmab052.

DOI:10.1093/labmed/lmab052

PMID:34268570

Abstract

OBJECTIVE

To clarify the prognostic values of hemostatic parameters to predict the survival of patients undergoing orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).

METHODS

The data of 182 consecutive adult patients who underwent OLT for HBV-related HCC were subjected to univariate and multivariate analyses.

RESULTS

Ascites and fibrinogen levels on postoperative day (POD) 1 were independent predictors of postoperative 2-year mortality (both P <.05). Kaplan-Meier survival analysis showed that the higher the fibrinogen level on POD 1, the better the 1- and 2-year survival of patients with ascites (P <.05), whereas the fibrinogen level on POD 1 was associated with 1-year (P <.05) but not 2-year survival of patients without ascites.

CONCLUSION

Fibrinogen on POD 1 is a predictor of 2-year post-OLT survival of patients with HBV-related HCC with ascites.

摘要

目的

阐明止血参数对预测乙型肝炎病毒（HBV）相关肝细胞癌（HCC）患者行原位肝移植（OLT）后生存情况的预后价值。

方法

对 182 例连续接受 OLT 治疗的 HBV 相关 HCC 成年患者的数据进行单因素和多因素分析。

结果

术后第 1 天的腹水和纤维蛋白原水平是术后 2 年死亡率的独立预测因素（均 P<.05）。Kaplan-Meier 生存分析显示，腹水患者第 1 天的纤维蛋白原水平越高，1 年和 2 年的生存率越高（P<.05），而第 1 天的纤维蛋白原水平与无腹水患者的 1 年生存率相关（P<.05），但与 2 年生存率无关。