先天性骨硬化症的小眼小鼠的血液学代偿
Hematological compensation of microphthalmic mice with congenital osteopetrosis.
作者信息
Wiktor-Jedrzejczak W, Pojda Z, Ahmed A, Ratajczak M Z
机构信息
Department of Immunology, Postgraduate Medical Center CKP WAM, Warsaw, Poland.
出版信息
Bone. 1987;8(5):315-7. doi: 10.1016/8756-3282(87)90008-1.
PMID:3426889
Abstract
Microphthalmic mice possess less than 10% of marrow cells. This marrow deficiency is compensated by an increase in the number of spleen cells. Additionally, 2-week-old mi/mi mice have increased frequency of hemopoietic stem cells in the spleen and remaining marrow. In addition they have persistent stem cells in the liver. No other major hematologic abnormalities were found.
摘要
小眼畸形小鼠的骨髓细胞数量不到正常小鼠的10%。这种骨髓缺陷通过脾细胞数量的增加得到补偿。此外，2周龄的mi/mi小鼠脾脏和剩余骨髓中的造血干细胞频率增加。此外，它们的肝脏中存在持续的干细胞。未发现其他主要血液学异常。
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