Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou; Department of Interventional Oncology, School of Medicine, Renji Hospital, Shanghai Jiao-Tong University, Shanghai, China.
Department of Interventional Oncology, School of Medicine, Renji Hospital, Shanghai Jiao-Tong University, Shanghai, China.
J Cancer Res Ther. 2021 Jul;17(3):638-643. doi: 10.4103/jcrt.JCRT_1421_20.
The aim was to study the changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation (RFA) of thyroid nodules in patients with autoimmune thyroiditis.
Patients (n = 135) with autoimmune thyroiditis and thyroid nodules were treated by RFA. The indices of thyroid function and thyroid antibody and T lymphocyte subsets were examined preoperation and on the 1 day and the 1 month after ablation. Any complications were recorded.
The software SPSS 17.0.0 (version: 2008-8-23) running under Windows 8 was used for statistical analysis. The measurement data were expressed as x ± s, with P < 0.01 indicating a significant difference in the statistical data.
Levels of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were in the normal range before ablation, and no significant changes occurred on the 1 day or in the 1 month after ablation. The change in the percentage of CD8+T cells and the absolute value of B cells were not statistically significant (P > 0.01), and the values were in the normal range. Compared with values recorded preoperation, the value of TG-Ab, TPO-Ab, CD4+/CD8+, the percentage of CD4+T cells, the absolute values of lymphocytes, T cells, CD4+T cells, and CD8+T cells decreased significantly at the 1 day after ablation (P < 0.01) and then recovered to preoperative levels during the first 30 days after ablation (P > 0.01). Within 1 month after ablation, none of the patients had complications such as active bleeding, infection, recurrent laryngeal nerve injury, parathyroid gland injury, skin scald, and so on.
After RFA of thyroid nodules in patients with autoimmune thyroiditis, thyroid function is not affected and no serious complications occurred. TG-Ab and TPO-Ab levels can be significantly decreased, and the distribution of T lymphocyte subsets can be changed in the short term after ablation.
本研究旨在探讨自身免疫性甲状腺炎合并甲状腺结节患者经射频消融（RFA）治疗后甲状腺抗体和 T 淋巴细胞亚群的变化。
对 135 例自身免疫性甲状腺炎合并甲状腺结节患者进行 RFA 治疗，检测术前、消融后 1 天和 1 个月患者甲状腺功能及甲状腺抗体和 T 淋巴细胞亚群的各项指标，记录有无并发症。
采用 SPSS 17.0.0 统计软件（Windows 8 版，2008-8-23）进行统计学分析，计量资料以均数±标准差（x±s）表示，组间比较采用 t 检验，以 P＜0.01 为差异有统计学意义。
消融前游离三碘甲状腺原氨酸、游离甲状腺素、促甲状腺激素水平均在正常范围，消融后 1 天和 1 个月上述指标与术前比较差异无统计学意义（P＞0.01）。CD8+T 细胞比例、B 细胞绝对值变化差异无统计学意义（P＞0.01），均在正常范围。与术前比较，TG-Ab、TPO-Ab、CD4+/CD8+、CD4+T 细胞比例、淋巴细胞计数、T 细胞计数、CD4+T 细胞计数、CD8+T 细胞计数在消融后 1 天均明显降低（P＜0.01），术后 30 天内逐渐恢复至术前水平（P＞0.01）。术后 1 个月内无活动性出血、感染、喉返神经损伤、甲状旁腺损伤、皮肤烫伤等并发症发生。
自身免疫性甲状腺炎合并甲状腺结节患者行 RFA 治疗后甲状腺功能不受影响，无严重并发症发生，短期内可明显降低甲状腺抗体水平，改变 T 淋巴细胞亚群分布。
