各种形式红斑狼疮患者外周血单个核细胞的自然杀伤细胞活性。

Natural killer cell activity of peripheral blood mononuclear cells from patients with various forms of lupus erythematosus.

作者信息

Błaszczyk M, Majewski S, Wasik M, Chorzelski T, Jabłonska S

机构信息

Department of Dermatology, Warsaw Medical Academy, Poland.

出版信息

Br J Dermatol. 1987 Dec;117(6):709-14. doi: 10.1111/j.1365-2133.1987.tb07350.x.

DOI:10.1111/j.1365-2133.1987.tb07350.x

PMID:3426951

Abstract

Natural killer (NK) cell activity of peripheral blood mononuclear cells from 28 patients with cutaneous discoid lupus erythematosus, seven with subacute cutaneous lupus erythematosus, and 17 with systemic lupus erythematosus was studied using a 4 h 51Cr release assay using K-562 cells as target cells. NK cell activity was found to be markedly decreased not only in patients with systemic lupus erythematosus but also in a proportion of cases of subacute cutaneous lupus erythematosus and cutaneous discoid lupus erythematosus (57% and 39% respectively). There was a relationship between the activity and severity of LE and the decrease in NK cell activity.

摘要

采用以K-562细胞为靶细胞的4小时51Cr释放试验，研究了28例盘状红斑狼疮、7例亚急性皮肤型红斑狼疮和17例系统性红斑狼疮患者外周血单个核细胞的自然杀伤（NK）细胞活性。结果发现，不仅系统性红斑狼疮患者的NK细胞活性显著降低，而且部分亚急性皮肤型红斑狼疮和盘状红斑狼疮患者（分别为57%和39%）的NK细胞活性也显著降低。NK细胞活性与红斑狼疮的活动度和严重程度之间存在关联，且NK细胞活性降低。