[他林洛尔（科达隆）引起的胆汁淤积性肝病？]
[Cholestatic hepatosis caused by Talinolol (Cordanum)?].
作者信息
Wiese M, Metzner C, Brunner H P, Klemm H P
出版信息
Z Gesamte Inn Med. 1979 Jan 15;34(2):86-8.
It is reported on a 38-year-old female patient who was treated for 18 days with 150 mg cordanum (talinolol) each and then fell ill with a dyspeptic clinical picture and signs of cholestase. The result of a liver biopsy was the picture of a cholestatic hepatosis. According to the results of the lymphocyte transformation test and the monocyte test as well as to the reexposition with following clinical recidivation the talinolol medication is to be regarded as cause. Pathogenetically is referred to the structural relations of talinolol to substances with paragroups as well as to a possible summation of different loads of the liver function.
据报道，一名38岁女性患者，每天服用150毫克科达隆（他林洛尔），持续治疗18天后，出现消化不良的临床表现和胆汁淤积症状。肝脏活检结果显示为胆汁淤积性肝病。根据淋巴细胞转化试验和单核细胞试验结果，以及再次用药后出现临床复发的情况，他林洛尔用药应被视为病因。从发病机制上看，这与他林洛尔与具有对位基团的物质的结构关系以及肝功能不同负荷的可能累加有关。
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