[Cardioselective beta receptor blockade in acute myocardial infarct with talinolol].

On 9 patients with acute myocardial infarction the influence of talinolol (cordanum) on haemodynamic parameters in intravenous administration and after this in oral application was examined. Talinolol led to a slight decrease of the heart rate, of the arterial blood pressure and of the cardiac output as well as to a more distinct reduction of the contractility in nearly uninfluenced left-ventricular filling pressure. In comparison to a conventionally treated control group (n = 11) the decrease of the heart rate as well as of the contractility was somewhat more distinct. The changes found are to be explained in the sense of a heart exoneration. In one patient possibly by talinolol a deterioration of the pumping function developed 56 hours after the acute event. In another patient a depressive effect on the sinus node is not to be excluded. Ventricular fibrillation and disturbances of the atrioventricular conduction did not appear in contrast to the control group. The influence on supraventricular and ventricular cardiac dysrhythmias was distinctly favourable in other 9 patients with acute myocardial infarction despite clinical signs of cardiac decompensation. Only in one patient a further deterioration of the pumping function developed despite control of the disturbance of rhythm. According to the experimental and up to now existing clinical experiences beta-receptor blockers are indicated above all in the early phase of the acute myocardial infarction, if shock, acute heart insufficiency and bradycardiac disturbances of the heart rhythm are not existing. Here paticularly at the beginning of the therapy is a proved change in the first 2-4(-8) hours to prevent the expansion of the infarct size or the onset of large infarctions.