Department of Geriatrics, Peking University First Hospital.
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University Health Science Center.
Int Heart J. 2021 Jul 30;62(4):752-755. doi: 10.1536/ihj.20-817. Epub 2021 Jul 17.
This study aimed to evaluate the concentration of plasma elabela (ELA) in patients with coronary heart disease (CHD) and its correlation with the disease classification.We enrolled 238 patients diagnosed by coronary angiography as CHD and 86 controls. The CHD group was divided into three subgroups: stable angina (SA), unstable angina (UAP), and acute myocardial infarction (AMI). The plasma levels of ELA were measured in all participants and compared among different groups. The relationship between ELA and CHD classification was analyzed.ELA levels were markedly higher by 10.71% in patients with CHD than in controls (P < 0.05). The concentration of ELA in UAP and AMI subgroups were higher than in controls and SA subgroup. The former difference was significant (P < 0.05), but the latter was not. In addition, the ELA concentration was not correlated with SYNTAX score, left ventricular ejection fraction, and other biochemical variables.The newfound hormone, ELA, significantly increased in patients with UAP and AMI. There is a tendency that ELA levels might be correlated with CHD classification, but not with lesion severity. ELA may play a role in acute coronary syndrome.
本研究旨在评估冠心病（CHD）患者血浆中 elabela（ELA）的浓度及其与疾病分类的相关性。我们纳入了 238 名经冠状动脉造影诊断为 CHD 的患者和 86 名对照者。CHD 组分为稳定型心绞痛（SA）、不稳定型心绞痛（UAP）和急性心肌梗死（AMI）三个亚组。所有参与者均测量了 ELA 的血浆水平，并比较了不同组之间的水平。分析了 ELA 与 CHD 分类的关系。与对照组相比，CHD 患者的 ELA 水平显著升高了 10.71%（P<0.05）。UAP 和 AMI 亚组的 ELA 浓度高于对照组和 SA 亚组。前一差异具有统计学意义（P<0.05），而后一差异则无统计学意义。此外，ELA 浓度与 SYNTAX 评分、左心室射血分数和其他生化变量均无相关性。这种新发现的激素 ELA 在 UAP 和 AMI 患者中明显升高。ELA 水平可能与 CHD 分类有关，但与病变严重程度无关，这一趋势存在。ELA 可能在急性冠状动脉综合征中发挥作用。
