Endocrine and Metabolism Research Center Institute of Basic and Clinical Physiology Sciences Kerman University of Medical Sciences Kerman Iran.
Pathology and Stem Cell Research Center Afzalipour Hospital Kerman University of Medical Sciences Kerman Iran.
Endocrinol Diabetes Metab. 2021 Jun 7;4(3):e00266. doi: 10.1002/edm2.266. eCollection 2021 Jul.
Thyroid cancer is the most common endocrine malignancy, and it has the fastest increase rate in incidence in both sexes, with a yearly increase of 3% over the last decade. Thyroid-stimulating hormone (TSH) is the main driver for the thyroid gland to produce thyroid hormone. The main purpose of this study was to assess the relationship between serum TSH level and the stage of malignancy in patients with differentiated thyroid cancer.
This cross-sectional study was performed on 77 patients with thyroid cancer. The demographic characteristics, TSH level and stage of malignancy were recorded for all patients in the data collection form. The data analysis was conducted by descriptive statistics using SPSS 20.0 software.
The results show a significant relationship (-value = .025) between the malignancy stage and serum TSH level. The mean TSH level in patients of stage 3 (5.70 ± 2.03) was significantly higher than patients in stage 2 (2.58 ± 0.52) and stage 1 (2.33 ± 0.28). No significant relationship was observed between the age of patients and serum TSH level. Although the mean serum TSH level in men (3.61 ± 0.98) was higher than in women (2.52 ± 0.25), the difference was not statistically significant.
According to the results of this study, serum TSH level can be considered as a predictor of the stage of differentiated thyroid cancer. Therefore, it can be used to predict the likelihood of cancer and improve the outcome and extent of thyroidectomy in patients with thyroid cancer.
甲状腺癌是最常见的内分泌恶性肿瘤，其在两性中的发病率增长速度最快，在过去十年中每年增长 3%。促甲状腺激素（TSH）是甲状腺产生甲状腺激素的主要驱动因素。本研究的主要目的是评估分化型甲状腺癌患者血清 TSH 水平与恶性程度分期之间的关系。
本横断面研究纳入了 77 例甲状腺癌患者。所有患者的人口统计学特征、TSH 水平和恶性程度分期均记录在数据采集表中。使用 SPSS 20.0 软件进行描述性统计分析。
结果显示，恶性程度分期与血清 TSH 水平之间存在显著关系（-值=0.025）。分期 3 组患者的 TSH 平均水平（5.70±2.03）显著高于分期 2 组（2.58±0.52）和分期 1 组（2.33±0.28）。患者年龄与血清 TSH 水平之间未观察到显著关系。虽然男性（3.61±0.98）的平均血清 TSH 水平高于女性（2.52±0.25），但差异无统计学意义。
根据本研究结果，血清 TSH 水平可作为分化型甲状腺癌分期的预测指标。因此，它可以用于预测癌症的可能性，并改善甲状腺癌患者的手术结果和范围。
