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袖状胃切除术后继发性无精子症：一例报告

Secondary azoospermia after sleeve gastrectomy: a case report.

作者信息

Gomez Gricelda, Berger Alexandra, Kathrins Martin

机构信息

Division of Urology, Brigham and Women's Hospital, Boston, Massachusetts.

出版信息

F S Rep. 2021 May 24;2(2):245-248. doi: 10.1016/j.xfre.2021.04.009. eCollection 2021 Jun.

DOI:10.1016/j.xfre.2021.04.009
PMID:34278361
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8267378/
Abstract

OBJECTIVE

To report the first case of secondary azoospermia after sleeve gastrectomy.

DESIGN

Case report.

SETTING

Academic male infertility clinic.

PATIENTS

A 33-year-old man with secondary azoospermia and primary testicular failure with testosterone deficiency after laparoscopic sleeve gastrectomy.

INTERVENTIONS

Hormonal therapy with anastrozole for 10 months and diagnostic testicular biopsy.

MAIN OUTCOME MEASURES

Semen analyses and testicular histopathology.

RESULTS

Non-obstructive azoospermia persisted at 20 months after surgery despite hormonal therapy with anastrozole. Testicular histopathology revealed the presence of Sertoli cells only.

CONCLUSIONS

Although further research is need to determine the relationship between sleeve gastrectomy and secondary infertility, men should be informed of the potentially deleterious effects of this surgery on semen parameters.

摘要

目的

报告首例袖状胃切除术后继发性无精子症病例。

设计

病例报告。

地点

学术性男性不育诊所。

患者

一名33岁男性，腹腔镜袖状胃切除术后出现继发性无精子症及原发性睾丸功能衰竭伴睾酮缺乏。

干预措施

使用阿那曲唑进行激素治疗10个月，并进行诊断性睾丸活检。

主要观察指标

精液分析和睾丸组织病理学检查。

结果

尽管使用阿那曲唑进行了激素治疗，但术后20个月仍持续存在非梗阻性无精子症。睾丸组织病理学检查显示仅存在支持细胞。

结论

尽管需要进一步研究以确定袖状胃切除术与继发性不育之间的关系，但应告知男性该手术对精液参数可能产生的有害影响。

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Factors influencing the choice between laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass.影响腹腔镜袖状胃切除术与Roux-en-Y胃旁路术选择的因素。
Surg Endosc. 2021 Aug;35(8):4691-4699. doi: 10.1007/s00464-020-07933-6. Epub 2020 Sep 9.
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Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery.男性肥胖相关性腺功能障碍与减重手术的作用。
Front Endocrinol (Lausanne). 2020 Jun 19;11:408. doi: 10.3389/fendo.2020.00408. eCollection 2020.
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Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures - 2019 Update: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic and Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists.肥胖与代谢外科围手术期营养、代谢及非手术支持临床实践指南 2019 年更新版：美国临床内分泌医师协会/美国内分泌学会、美国肥胖学会、美国代谢与减肥外科学会、肥胖医学协会及美国麻醉医师学会共同赞助
Obesity (Silver Spring). 2020 Apr;28(4):O1-O58. doi: 10.1002/oby.22719.
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Changes in total sperm count after gastric bypass and sleeve gastrectomy: the BARIASPERM prospective study.胃旁路和袖状胃切除术后总精子数的变化：BARIASPERM 前瞻性研究。
Surg Obes Relat Dis. 2019 Aug;15(8):1271-1279. doi: 10.1016/j.soard.2019.04.019. Epub 2019 Apr 25.
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Effect of Bariatric Surgery on Semen Parameters: A Systematic Review and Meta-Analysis.减肥手术对精液参数的影响：一项系统评价与荟萃分析。
Med Sci Monit Basic Res. 2018 Nov 12;24:188-197. doi: 10.12659/MSMBR.910862.
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Impact of Bariatric Surgery on Male Sex Hormones and Sperm Quality: a Systematic Review and Meta-Analysis.减重手术对男性性激素和精子质量的影响：系统评价和荟萃分析。
Obes Surg. 2019 Jan;29(1):334-346. doi: 10.1007/s11695-018-3557-5.
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ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.美国代谢与减肥外科学会儿科代谢与减重手术指南，2018 年。
Surg Obes Relat Dis. 2018 Jul;14(7):882-901. doi: 10.1016/j.soard.2018.03.019. Epub 2018 Mar 23.
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MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches.MOSH 综合征（男性肥胖继发性性腺功能减退症）：临床评估及可能的治疗方法。
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