Department of Endocrinology, Auckland City Hospital, Auckland, New Zealand.
Intern Med J. 2021 Jul;51(7):1016-1020. doi: 10.1111/imj.14992.
Immune checkpoint inhibitors are increasingly being utilised as an effective therapy for a variety of cancers. However, they have the potential to cause serious autoimmune toxicities in multiple organ systems termed 'immunotherapy-related adverse events'. Endocrine toxicities are common, can occur well after commencement of therapy and can result in significant morbidity and mortality if not recognised. This makes it important for all physicians, in addition to endocrinologists and oncologists, to understand the nature of these reactions and the general approach to their diagnosis and management. This review aims to provide an overview of the epidemiology, pathophysiology, clinical presentation and management of the endocrine adverse events.
免疫检查点抑制剂越来越多地被用作多种癌症的有效治疗方法。然而，它们有可能在多个器官系统中引起严重的自身免疫毒性，称为“免疫治疗相关不良事件”。内分泌毒性很常见，在治疗开始后很久才会发生，如果不及时发现，可能会导致严重的发病率和死亡率。这使得所有医生，不仅是内分泌学家和肿瘤学家，都需要了解这些反应的性质以及诊断和管理的一般方法。这篇综述旨在概述内分泌不良事件的流行病学、病理生理学、临床表现和管理。
