18FDG 正电子发射断层扫描在结核性脑膜炎患者中的应用：一项前瞻性评估。
18FDG-Positron Emission Tomography in patients with Tuberculous Meningitis: A Prospective Evaluation.
机构信息
Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
出版信息
Am J Trop Med Hyg. 2021 Jul 19;105(4):1038-1041. doi: 10.4269/ajtmh.21-0102.
Lower yield of available diagnostic tests for tuberculous meningitis (TBM) frequently causes delay in diagnosis. Recently, 18F-fluorodeoxyglucose positron emission tomography (FDG PET) has been used in infectious disorders such as pulmonary tuberculosis; however, it is rarely used in TBM. This study was aimed to ascertain the role of FDG PET in the diagnosis and determination of the extent of disease and prognosis in patients with TBM. After excluding unsuitable patients, 25 patients were subjected to whole-body PET-computed tomography (CT) image acquisition along with separate brain protocol with an integrated PET-CT device. FDG PET was found to be abnormal in 92% patients. Extracranial FDG uptake was observed in 80% patients. Most common extracranial site of involvement was lymph nodes (60%), followed by lung (56%), vertebral body (8%), genitourinary organs (8%), and spleen (4%). FDG PET observed extracranial involvement had 80% sensitivity and 20% specificity in detecting definite TBM cases. In conclusion, FDG PET may be a useful test in TBM evaluation.
结核性脑膜炎（TBM）的诊断性检测有效率较低，常导致诊断延误。氟代脱氧葡萄糖正电子发射断层扫描（FDG PET）最近已用于肺结核等感染性疾病，但在 TBM 中很少使用。本研究旨在确定 FDG PET 在 TBM 患者的诊断以及确定疾病程度和预后方面的作用。排除不适合的患者后，25 名患者使用集成 PET-CT 设备进行全身 PET-CT 图像采集和单独的脑部方案。92%的患者 FDG PET 异常。80%的患者存在颅外 FDG 摄取。最常见的颅外受累部位是淋巴结（60%），其次是肺（56%）、椎体（8%）、泌尿生殖器官（8%）和脾脏（4%）。FDG PET 观察到的颅外受累在检测明确的 TBM 病例时具有 80%的敏感性和 20%的特异性。总之，FDG PET 可能是 TBM 评估的有用测试。
Zotero 插件