Diabetology Clinic, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, Belgium.
J Pediatr Endocrinol Metab. 2021 Jul 20;34(10):1319-1322. doi: 10.1515/jpem-2021-0289. Print 2021 Oct 26.
Questions are emerging concerning the long-term consequences of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, as a possible increase in type 1 diabetes. This study aims to describe the prevalence of anti-SARS-CoV-2 antibodies in children developing type 1 diabetes during this pandemic in Belgium.
This observational study included children and adolescents (under 16 years) admitted with new-onset type 1 diabetes. SARS-CoV-2 serology was taken within the first month of diabetes.
Of the 75 participants, anti-SARS-CoV-2 antibodies were positive in 20% of patients. They had an increased bicarbonate and base excess at diagnosis. Overall 29% of patients presented diabetic ketoacidosis at diagnosis and 9% of them were positive for anti-SARS-CoV-2 antibodies. Insulinoma-associated protein 2 antibodies positivity had significantly higher frequencies in children without anti-SARS-CoV-2 antibodies (49 (81%) vs. 5 (33%), p=0.038). Nine (15%) patients, initially seronegative, have developed anti-SARS-CoV-2 antibodies between the two samples (mean time 8 ± 4 weeks).
The prevalence of anti-SARS-CoV-2 antibodies in children with newly diagnosed type 1 diabetes (20%) is similar to that found in children without diabetes in Belgium, a country severely affected by this pandemic.
随着严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 大流行后可能出现 1 型糖尿病病例增多，人们开始关注其长期影响。本研究旨在描述比利时 SARS-CoV-2 大流行期间新诊断为 1 型糖尿病的儿童中抗 SARS-CoV-2 抗体的流行情况。
这是一项观察性研究，纳入了新诊断为 1 型糖尿病的儿童和青少年（<16 岁）。在糖尿病发病后第一个月内进行 SARS-CoV-2 血清学检测。
在 75 名参与者中，20%的患者抗 SARS-CoV-2 抗体呈阳性。他们在诊断时碳酸氢盐和碱剩余增加。总体而言，29%的患者在诊断时存在糖尿病酮症酸中毒，其中 9%的患者抗 SARS-CoV-2 抗体呈阳性。无抗 SARS-CoV-2 抗体的儿童胰岛素瘤相关蛋白 2 抗体阳性率显著更高（49（81%）vs. 5（33%），p=0.038）。9（15%）例最初血清学阴性的患者在两次采样之间出现抗 SARS-CoV-2 抗体（平均时间 8±4 周）。
新诊断为 1 型糖尿病的儿童中抗 SARS-CoV-2 抗体的流行率（20%）与比利时无糖尿病儿童相似，该国受该大流行影响严重。
