Ye Ziping, Liu Fuyao, Ma Jia, Zhou Ziyang, Wang Chen, Sun Lihua
College of business administration, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Cost Eff Resour Alloc. 2021 Jul 19;19(1):45. doi: 10.1186/s12962-021-00298-0.
The payment card (PC) format and the open-ended (OE) format are common methods in eliciting willingness-to-pay (WTP) of one additional quality-adjusted life year (QALY). The aim of this research is to compare these two formats in eliciting the monetary value of a QALY.
A contingent valuation survey was carried out using a pre-designed questionnaire with various hypothetical scenarios. The difference between the PC and the OE formats was evaluated by a two-sample equality test. Furthermore, generalized linear models were carried out to control observed heterogeneity and to test theoretical validity.
In total, 461 individuals were involved, among whom 235 (51%) answered the PC question, while 226 (49%) answered the OE question. Excluding zero response, the mean WTP values of these two formats for different scenarios varied dramatically, which was from 13,278 to 280,177 RMB for the PC, 18,119 to 620,913 RMB for the OE. The OE format tended to elicit lower values for less serious condition and higher values for more serious condition. However, equality test of mean and median demonstrated insignificant difference of these two formats for all scenarios. For both OE and PC format, most variables were found to have significant effect on the value of WTP/QALY. Moreover, joint estimation indicated a statistically significant positive effect on the OE results. Further analysis demonstrated that the imbalanced zero response distribution caused the main difference of these two formats.
This research indicated insignificantly different WTP/QALY estimates of the PC format and OE format with the grouped data whereas significantly higher estimates of the OE format from the pooled data. These two formats were found to be valid. More research about the difference and the validity of various WTP eliciting methods would be recommended for a robust estimation of WTP/QALY.
支付卡(PC)形式和开放式(OE)形式是引出额外一个质量调整生命年(QALY)支付意愿(WTP)的常用方法。本研究的目的是比较这两种形式在引出QALY货币价值方面的差异。
使用预先设计的包含各种假设情景的问卷进行了一项条件价值评估调查。通过双样本相等性检验评估PC形式和OE形式之间的差异。此外,进行了广义线性模型以控制观察到的异质性并检验理论有效性。
总共461人参与,其中235人(51%)回答了PC问题,而226人(49%)回答了OE问题。排除零应答后,这两种形式在不同情景下的平均WTP值差异很大,PC形式从13278元到280177元,OE形式从18119元到620913元。OE形式在病情较轻时倾向于引出较低的值,在病情较重时倾向于引出较高的值。然而,均值和中位数的相等性检验表明这两种形式在所有情景下的差异均不显著。对于OE和PC形式,大多数变量对WTP/QALY值都有显著影响。此外,联合估计表明对OE结果有统计学上显著的正向影响。进一步分析表明,零应答分布不均衡导致了这两种形式的主要差异。
本研究表明,分组数据中PC形式和OE形式的WTP/QALY估计值差异不显著,而合并数据中OE形式的估计值显著更高。发现这两种形式都是有效的。建议对各种WTP引出方法的差异和有效性进行更多研究,以稳健估计WTP/QALY。