Serradell J, Bjornson D C, Hartzema A G
Department of Social and Administrative Pharmacy, College of Pharmacy, University of Minnesota, Minneapolis.
Drug Intell Clin Pharm. 1987 Dec;21(12):994-1001. doi: 10.1177/106002808702101216.
This paper in the series on pharmacoepidemiology describes the history, development, and present status of drug utilization activities. The various methodologies employed in drug utilization studies are evaluated and presented along with a listing of the principal drug databases available for drug utilization research. An analysis is presented comparing the validity of drug consumption rates based on individual patient usage or drug cost data as adopted in North America and the defined daily dose unit as developed in Europe. Drug utilization derives its importance in pharmacoepidemiology from the fact that it provides the methodological rigor for defining the denominator data needed in pharmacoepidemiological research.
本系列关于药物流行病学的论文描述了药物利用活动的历史、发展和现状。对药物利用研究中采用的各种方法进行了评估，并列出了可用于药物利用研究的主要药物数据库。本文还进行了一项分析，比较了基于北美采用的个体患者用药情况或药物成本数据得出的药物消费率与欧洲制定的限定日剂量单位的有效性。药物利用在药物流行病学中的重要性源于这样一个事实，即它为确定药物流行病学研究所需的分母数据提供了方法上的严谨性。
