Department of Gynaecology and Obstetrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic.
Department of Pathological Anatomy, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021 Sep;165(3):328-331. doi: 10.5507/bp.2021.044. Epub 2021 Jul 20.
Coronavirus disease 2019 is responsible for a worldwide increase in morbidity and mortality. The relationship of this infection to mother-to-child vertical transmission has not been elucidated yet. However, recent reports indicate a foetal death rate of up to 3%.
We report a case of sudden pre-term foetal demise in a woman positive for SARS-CoV-2 but asymptomatic, with physiological course of pregnancy.
One of the possible explanations of sudden foetal death may be acute placental insufficiency caused by a SARS-CoV-2 placental infection or the development of foetal inflammatory response syndrome (FIRS).
Considering the potential risk of foetal demise, questions remain regarding foetal monitoring and the timing of labour and delivery in the second and third trimesters, particularly in asymptomatic or mild maternal SARS-CoV-2 infection. A relevant multidisciplinary team must also be aware of these risks associated with possibly fatal consequences.
2019 年冠状病毒病导致全球发病率和死亡率上升。这种感染与母婴垂直传播的关系尚未阐明。然而，最近的报告表明胎儿死亡率高达 3%。
我们报告了一例在 SARS-CoV-2 检测呈阳性但无症状、妊娠生理过程正常的孕妇中突然发生的早产胎儿死亡病例。
胎儿突然死亡的一个可能解释可能是由 SARS-CoV-2 胎盘感染或胎儿炎症反应综合征（FIRS）引起的急性胎盘功能不全。
考虑到胎儿死亡的潜在风险，对于第二和第三个孕期的胎儿监测以及分娩时机仍存在疑问，特别是在母体 SARS-CoV-2 感染无症状或轻度的情况下。相关多学科团队也必须意识到这些可能导致致命后果的风险。
