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在多替拉韦时代监测撒哈拉以南非洲地区新发的人类免疫缺陷病毒耐药性。

Monitoring Emerging Human Immunodeficiency Virus Drug Resistance in Sub-Saharan Africa in the Era of Dolutegravir.

机构信息

Division of Global HIV & TB, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

US Department of State, Washington, Dsitrict of Columbia, USA.

出版信息

J Infect Dis. 2022 Feb 1;225(3):364-366. doi: 10.1093/infdis/jiab382.

Abstract

Dolutegravir-based regimens are now standard of care for human immunodeficiency virus treatment for millions of people around sub-Saharan Africa. To ensure its continued efficacy, monitoring of emerging drug resistance that inform a treatment strategy among those failing is crucial. In this report, we outline the US President's Emergency Plan for AIDS Relief to leverage viral load infrastructure to implement effective drug resistance surveillance in the countries it supports.

摘要

基于度鲁特韦的方案目前是撒哈拉以南非洲地区数百万人的人类免疫缺陷病毒治疗的标准护理。为了确保其持续疗效,监测新出现的耐药性对于那些失败的患者制定治疗策略至关重要。在本报告中,我们概述了美国总统艾滋病紧急救援计划,利用病毒载量基础设施在其支持的国家实施有效的耐药性监测。

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