Biochemistry Department, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.
Central Research Testing and Analysis Laboratory Research and Application Center, Ege University, 35100, Bornova, Izmir, Turkey.
Bioconjug Chem. 2021 Aug 18;32(8):1491-1502. doi: 10.1021/acs.bioconjchem.1c00285. Epub 2021 Jul 20.
Chemotherapy has seen great progress in the development of performant treatment strategies. Nanovesicles such as liposomes and polymersomes demonstrated great potential in cancer therapy. However, these nanocarriers deliver their content passively, which faces a lot of constraints during blood circulation. The main challenge resides in degradation and random delivery to normal tissues. Hence, targeting drug delivery using specific molecules (such as antibodies) grafted over the surface of these nanocarriers came as the answer to overcome many problems faced before. The advantage of using antibodies is their antigen/antibody recognition, which provides a high level of specificity to reach treatment targets. This review discusses the many techniques of nanocarrier functionalization with antibodies. The aim is to recognize the various approaches by describing their advantages and deficiencies to create the most suitable drug delivery platform. Some methods are more suitable for other applications rather than drug delivery, which can explain the low success of some proposed targeted nanocarriers. In here, a critical analysis of how every method could impact the recognition and targeting capacity of some nanocarriers (liposomes and polymersomes) is discussed to make future research more impactful and advance the field of biomedicine further.
化疗在开发高效治疗策略方面取得了巨大进展。脂质体和聚合物囊泡等纳米囊泡在癌症治疗中显示出巨大的潜力。然而，这些纳米载体被动地传递其内容物，这在血液循环中面临许多限制。主要挑战在于降解和随机递送到正常组织。因此，使用特定分子（如抗体）靶向药物递送，接枝在这些纳米载体的表面上，成为克服以前面临的许多问题的答案。使用抗体的优点是其抗原/抗体识别，这为达到治疗靶点提供了高度的特异性。本文综述了纳米载体与抗体功能化的许多技术。目的是通过描述它们的优缺点来识别各种方法，从而创建最合适的药物递送平台。有些方法更适合其他应用，而不是药物递送，这可以解释为什么一些提出的靶向纳米载体的成功率较低。在这里，讨论了每种方法如何影响某些纳米载体（脂质体和聚合物囊泡）的识别和靶向能力，以提高未来研究的影响力，并进一步推动生物医学领域的发展。
