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pH/温度/氧化还原与光响应性聚合物囊泡的结构及其在癌症治疗中的应用:智能药物递送与靶向药物释放

pH/ Temperature/ Redox and Light-responsive Polymersome Structure and Application in Cancer Therapy: Smart Drug Delivery and Targeted Drug Release.

作者信息

Soleymani Sina, Naghib Seyed Morteza, Mozafari M R

机构信息

Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran 1684613114, Iran.

Australasian Nanoscience and Nanotechnology Initiative (ANNI), Monash University LPO, Clayton, VIC 3168, Australia.

出版信息

Curr Med Chem. 2025;32(22):4456-4480. doi: 10.2174/0109298673303351240507113603.

Abstract

Improvements in cancer treatment are largely influenced by more people knowing about it and developing new ways to diagnose and treat it. New methods such as nanotheranostics and the use of tiny particles have greatly improved the diagnosis, control and treatment of cancer. They have also helped overcome problems with traditional treatments. Nanotheranostics contribute to personalized medicine by helping doctors choose the right treatment, track how well the treatment works, and plan future treatments. Polymers have many advantages as smart or durable drug formulations among small therapeutic platforms. These small sacks, which can be used for drug delivery and imaging, are not harmful to natural tissues and are becoming more popular. Scientists have found a special group of tiny particles made of polymers that can carry active ingredients. These particles show the potential of creating a useful platform for the diagnosis and treatment of diseases on a very small scale. In the past ten years, people have become more interested in polymersomes. They have been used for various medical purposes, such as controlling blood sugar, treating cancer and fighting bacteria. Polymers are stronger and more stable than liposomes. Biocompatible and biodegradable polymers are very important for faster translation and creation of useful medical formulations. Recent progress in this field includes the creation of intelligent, centralized and responsive containers. In this review, we will examine and provide information about polymersomes. We will discuss their properties and how they can be used as drug delivery systems.

摘要

癌症治疗的改善在很大程度上受到更多人了解癌症并开发新的诊断和治疗方法的影响。诸如纳米诊疗学和使用微小颗粒等新方法极大地改善了癌症的诊断、控制和治疗。它们还帮助克服了传统治疗方法存在的问题。纳米诊疗学通过帮助医生选择正确的治疗方法、跟踪治疗效果以及规划未来治疗方案,为个性化医疗做出了贡献。在小型治疗平台中,聚合物作为智能或耐用的药物制剂具有许多优势。这些可用于药物递送和成像的小囊对天然组织无害,并且越来越受欢迎。科学家们发现了一种由聚合物制成的特殊微小颗粒群,它们能够携带活性成分。这些颗粒显示出在非常小的规模上为疾病诊断和治疗创建有用平台的潜力。在过去十年中,人们对聚合物囊泡越来越感兴趣。它们已被用于各种医疗目的,如控制血糖、治疗癌症和对抗细菌。聚合物比脂质体更强、更稳定。生物相容性和可生物降解的聚合物对于更快地转化和创建有用的医疗制剂非常重要。该领域的最新进展包括创建智能、集中和响应性的容器。在这篇综述中,我们将研究并提供有关聚合物囊泡的信息。我们将讨论它们的特性以及它们如何用作药物递送系统。

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