Ethnicity-stratified analysis of the association between P53 rs1042522 polymorphism and women HPV infection: A meta-analysis.

BACKGROUND

Human papillomavirus (HPV) infection, especially persistent high risk HPV infection stands as the leading reason for cervical cancer morbidity. P53 protein can activate multiple tumor suppressor genes, leading to cervical cancer progression. In recent years, the relationship between P53 gene rs1042522 polymorphism and HPV infection has been investigated. However, their conclusions were contradictory and ambiguous.

OBJECTIVES

The present meta-analysis is to estimate whether P53 rs1042522 polymorphism confers risk to HPV infection in cervical specimens.

METHODS

Relevant literatures were searched by searching databases including Pubmed, Embase, the Cochrane library, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to January 2021.

RESULTS

Eight literatures were enrolled in the present meta-analysis. Positive finding between HPV infection of cervical specimens and P53 rs1042522 polymorphism was found in Brazilian population by allele contrast (Pro versus. Arg: OR = 0.52, 95%CI = 0.35-0.79), homozygote comparison (Pro/Pro versus. Arg/Arg: OR = 0.43, 95%CI = 0.20-0.94), and dominate genetic model (Pro/Pro + Arg/Pro versus. Arg/Arg: OR = 0.29, 95%CI = 0.09-0.93). The similar phenomenon was also found in Arabian population.

CONCLUSION

We conclude that P53 rs1042522 polymorphism contributed a decreased risk to HPV infection in Brazilian and Arabian population.