National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA.
National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA; Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Neuroimage Clin. 2021;31:102752. doi: 10.1016/j.nicl.2021.102752. Epub 2021 Jul 3.
We recorded magnetoencephalography data during a visual recognition task in participants with combat exposure (n = 40, age: 41.2 ± 7.2 years) to investigate the relationship between the evoked brain activity, behavioral performance, and the severity of their post-traumatic stress symptoms assessed using the PTSD Check List for DSM V version (PCL-5). In an initial study session, participants were presented with a series of images of outdoor scenes and were instructed to study the images for an upcoming recognition test. In a subsequent session, the original images were shown intermixed with novel images while participants performed the recognition task. PCL-5 scores were negatively correlated with discrimination performance and with the recognition accuracy for original images. During the recognition session, higher PCL-5 scores were associated with reduced relative power of the evoked response to original images from 100 ms to 300 ms following the image onset over a distributed brain network including the bilateral inferior frontal gyri, left middle frontal gyrus, left supramarginal gyrus, right precuneus and the bilateral superior temporal gyri. These findings indicate that the lower recognition performance in participants with higher PTSD symptom severity is associated with altered cortical activity in brain regions that are known to play a role in the elaboration on visual cues that supports recollection.
我们在有战斗经历的参与者（n=40，年龄：41.2±7.2 岁）进行视觉识别任务期间记录了脑磁图数据，以研究诱发脑活动、行为表现与 PTSD 检查表第五版（PCL-5）评估的创伤后应激症状严重程度之间的关系。在最初的研究阶段，参与者观看了一系列户外场景的图像，并被指示学习这些图像，以备即将到来的识别测试。在随后的阶段，参与者在执行识别任务时，将原始图像与新图像混合展示。PCL-5 评分与辨别表现和原始图像的识别准确性呈负相关。在识别阶段，PCL-5 评分较高与原始图像诱发反应的相对功率降低有关，从图像出现后 100ms 到 300ms，分布在包括双侧额下回、左侧额中回、左侧缘上回、右侧楔前叶和双侧颞上回的脑网络中。这些发现表明，PTSD 症状严重程度较高的参与者的识别表现较低与大脑区域的皮层活动改变有关，这些区域已知在对支持回忆的视觉线索的详细阐述中发挥作用。
