全球极低出生体重早产儿长期神经发育损伤的流行情况：系统文献回顾。
Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review.
机构信息
Global Evidence and Outcomes, Takeda, Lexington, MA, USA.
Evidence Synthesis, Modeling & Communication, Evidera, London, UK.
出版信息
J Int Med Res. 2021 Jul;49(7):3000605211028026. doi: 10.1177/03000605211028026.
OBJECTIVE
Neurodevelopmental impairment (NDI) is a major complication of extreme prematurity. This systematic review was conducted to summarize the worldwide long-term prevalence of NDI associated with extreme prematurity.
METHODS
Embase and MEDLINE databases were searched for epidemiologic and observational/real-world studies, published in English between 2011 and 2016, reporting long-term prevalence of NDI (occurring from 1 year) among extremely preterm infants born at gestational age (GA) ≤28 weeks.
RESULTS
Of 2406 articles identified through searches, 69 met the protocol NDI definition (24 North America, 25 Europe, 20 Rest of World). Prevalence of any severity NDI in North America was 8%-59% at 18 months to 2 years, and 11%-37% at 2-5 years; prevalence of moderate NDI in Europe was 10%-13% at 18 months to 2 years, 3% at 2-5 years, and 9%-19% at ≥5 years; prevalence of any NDI in Rest of World was 15%-61% at 18 months to 2 years, and 42% at 2-5 years (no North America/Rest of World studies reported any NDI at ≥5 years). A trend toward higher prevalence of NDI with lower GA at birth was observed.
CONCLUSIONS
Extreme prematurity has a significant long-term worldwide impact on neurodevelopmental outcomes.
目的
神经发育障碍（NDI）是极早产儿的主要并发症。本系统评价旨在总结全球范围内与极早产儿相关的 NDI 的长期患病率。
方法
检索 Embase 和 MEDLINE 数据库，以获取 2011 年至 2016 年间发表的、关于极早产儿（胎龄（GA）≤28 周）出生后 1 年以上的 NDI 长期患病率的流行病学和观察性/真实世界研究的英文文章。
结果
通过检索共确定了 2406 篇文章，其中 69 篇符合方案中 NDI 定义（北美 24 篇，欧洲 25 篇，世界其他地区 20 篇）。北美极早产儿在 18 个月至 2 岁时，任何严重程度的 NDI 患病率为 8%-59%，2-5 岁时为 11%-37%；欧洲极早产儿在 18 个月至 2 岁时，中度 NDI 的患病率为 10%-13%，2-5 岁时为 3%，≥5 岁时为 9%-19%；世界其他地区极早产儿在 18 个月至 2 岁时，任何程度的 NDI 患病率为 15%-61%，2-5 岁时为 42%（北美/世界其他地区没有研究报告≥5 岁时的任何 NDI）。观察到随着出生时 GA 的降低，NDI 的患病率呈上升趋势。
结论
极早产对神经发育结局具有显著的全球性长期影响。
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