大鼠和人肝脏维生素K环氧化物还原酶：硫醇阻断剂和维生素K1的抑制作用
Rat and human liver vitamin K epoxide reductase: inhibition by thiol blockers and vitamin K1.
作者信息
Wallin R, Patrick S D, Martin L F
机构信息
Department of Physiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
出版信息
Int J Biochem. 1987;19(11):1063-8. doi: 10.1016/0020-711x(87)90307-7.
PMID:3428478
Abstract
- Reduction of vitamin K1 2,3-epoxide by rat and human liver vitamin K epoxide reductase is inhibited by N-ethylmaleimide and iodoacetamide. 2. Both enzymes are protected from inhibition by N-ethylmaleimide by vitamin K1 or vitamin K1 2,3-epoxide. 3. Vitamin K1 inhibits reduction of vitamin K1 2,3-epoxide to vitamin K1 which suggests product inhibition of the enzyme.
摘要
- 大鼠和人肝脏维生素K环氧化物还原酶对维生素K1 2,3-环氧化物的还原作用受到N-乙基马来酰亚胺和碘乙酰胺的抑制。2. 维生素K1或维生素K1 2,3-环氧化物可保护这两种酶免受N-乙基马来酰亚胺的抑制。3. 维生素K1抑制维生素K1 2,3-环氧化物还原为维生素K1，这表明该酶存在产物抑制作用。
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