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癫痫性停搏:一种不常见但意义重大的短暂意识丧失病因——病例系列研究。

Ictal asystole: an uncommon but significant cause of transient loss of consciousness-a case series.

机构信息

Department of Medicine for the Elderly, Queen Elizabeth University Hospital Campus, Glasgow, UK

Department of Medicine for the Elderly, Queen Elizabeth University Hospital Campus, Glasgow, UK.

出版信息

BMJ Case Rep. 2021 Jul 20;14(7):e240268. doi: 10.1136/bcr-2020-240268.

DOI:10.1136/bcr-2020-240268
PMID:34285016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8292728/
Abstract

Ictal bradycardia and asystole are rare, but potentially serious complications of epileptic seizures. We present a case series of three such patients diagnosed through our syncope service. For two patients, treatment with anticonvulsant therapy alone achieved symptom control. The third patient was initially managed with permanent pacemaker insertion due to detection of a significant ventricular pause. He subsequently developed more pronounced symptoms suggestive of seizure.Ictal asystole can cause significant diagnostic challenge and management strategies remain controversial due to the overlap in presentation to cardiology and neurology services. The number of patients affected is low, impeding the formulation of an evidence base for treatment. We propose multidisciplinary working facilitated by a specialist syncope service as a means of recognising and treating this condition more effectively.

摘要

癫痫发作时的心动过缓和心搏停止是罕见但潜在严重的并发症。我们通过晕厥服务诊断了三例此类患者。对于两名患者,单独使用抗癫痫药物治疗即可控制症状。第三名患者最初因检测到明显的心室停搏而接受了永久性起搏器植入。随后,他出现了更明显的癫痫发作症状。心搏停止可能会导致重大的诊断挑战,由于心血管病和神经病学服务之间的表现存在重叠,管理策略仍存在争议。受影响的患者人数较少,这阻碍了制定治疗证据基础。我们建议通过专门的晕厥服务促进多学科合作,以更有效地识别和治疗这种病症。

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1
Ictal asystole: an uncommon but significant cause of transient loss of consciousness-a case series.癫痫性停搏:一种不常见但意义重大的短暂意识丧失病因——病例系列研究。
BMJ Case Rep. 2021 Jul 20;14(7):e240268. doi: 10.1136/bcr-2020-240268.
2
Syncope, Epilepsy and Ictal Asystole: A Case Series and Narrative Review.晕厥、癫痫与癫痫性心搏停止:病例系列与叙述性综述
Heart Lung Circ. 2022 Jan;31(1):25-31. doi: 10.1016/j.hlc.2021.07.003. Epub 2021 Aug 6.
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Ictal asystole and ictal syncope: insights into clinical management.发作性心搏停止与发作性晕厥:临床管理见解
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Asystole induced by partial seizures: a rare cause of syncope.部分性癫痫发作诱发的心搏停止:晕厥的罕见原因。
Pacing Clin Electrophysiol. 2007 Nov;30(11):1416-9. doi: 10.1111/j.1540-8159.2007.00883.x.
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Comparison of clinical and electrophysiological characteristics between ictal and cardiac asystole encountered during video-EEG monitoring.在视频脑电图监测期间遇到的发作期和心脏停搏的临床和电生理特征比较。
Epileptic Disord. 2019 Aug 1;21(4):337-346. doi: 10.1684/epd.2019.1085.
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Epileptic seizures associated with syncope: Ictal bradycardia and ictal asystole.与晕厥相关的癫痫发作:发作期心动过缓和发作期心搏停止。
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Characterization of seizure-induced syncopes: EEG, ECG, and clinical features.癫痫发作引起的晕厥的特征:脑电图、心电图和临床特征。
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Syncope, seizure-induced bradycardia and asystole: two cases and review of clinical and pathophysiological features.晕厥、癫痫诱发的心动过缓和心搏停止:两例病例及临床和病理生理特征综述
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Ictal asystole in temporal lobe epilepsy before and after pacemaker implantation.起搏器植入前后颞叶癫痫发作期心搏停止
Epileptic Disord. 2008 Mar;10(1):39-44. doi: 10.1684/epd.2008.0166.

本文引用的文献

1
Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions.癫痫中的电压门控钠通道基因:突变、功能研究及治疗维度
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Neuro-arrhythmology: a challenging field of action and research: a review from the Task Force of Neuro-arrhythmology of Italian Association of Arrhythmias and Cardiac Pacing.神经心律失常学:充满挑战的行动和研究领域:意大利心律失常和心脏起搏协会神经心律失常学工作组的综述。
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Ictal asystole: a diagnostic and management conundrum.发作性心搏停止:诊断与处理难题
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4
Epileptic seizures associated with syncope: Ictal bradycardia and ictal asystole.与晕厥相关的癫痫发作:发作期心动过缓和发作期心搏停止。
Epilepsy Behav. 2019 Jan;90:168-171. doi: 10.1016/j.yebeh.2018.10.027. Epub 2018 Dec 19.
5
Keeping pace: A 38-second ictal asystole revealed during simultaneous electroencephalogram and electrocardiogram monitoring.同步:在脑电图和心电图同步监测期间发现38秒的发作性心搏停止。
HeartRhythm Case Rep. 2017 Dec 15;4(2):73-76. doi: 10.1016/j.hrcr.2017.11.007. eCollection 2018 Feb.
6
Long-Term Follow-Up of Ictal Asystole in Temporal Lobe Epilepsy: Is Permanent Pacemaker Therapy Needed?颞叶癫痫发作性心搏停止的长期随访:是否需要永久性起搏器治疗?
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Ictal asystole: life-threatening vagal storm or a benign seizure self-termination mechanism?发作性心搏停止:危及生命的迷走神经风暴还是良性癫痫自动终止机制?
Circ Arrhythm Electrophysiol. 2015 Feb;8(1):11-4. doi: 10.1161/CIRCEP.114.002546.
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Ictal asystole as the first presentation of epilepsy: A case report and systematic literature review.癫痫首次发作表现为发作期心脏停搏:一例病例报告及系统文献综述
Epilepsy Behav Case Rep. 2014 Aug 19;2:136-41. doi: 10.1016/j.ebcr.2014.06.001. eCollection 2014.
9
Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study.癫痫监测单元中心跳呼吸骤停的发生率和机制(MORTEMUS):一项回顾性研究。
Lancet Neurol. 2013 Oct;12(10):966-77. doi: 10.1016/S1474-4422(13)70214-X. Epub 2013 Sep 4.
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2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA).2013年欧洲心脏病学会(ESC)心脏起搏与心脏再同步治疗指南:欧洲心脏病学会(ESC)心脏起搏与再同步治疗特别工作组。与欧洲心律协会(EHRA)合作制定。
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