Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
Aging (Albany NY). 2021 Jul 20;13(14):18769-18788. doi: 10.18632/aging.203321.
The dopamine receptor-related loci have been suggested to be associated with cognitive functions and neurodegenerative diseases. It is unknown whether genetic variants such as single nucleotide polymorphisms (SNPs) in the dopamine receptor-related loci could contribute to cognitive aging independently as well as by virtue of complicated interplays in the elder population. To assess whether SNPs in the dopamine receptor-related loci are associated with cognitive aging in the elder population, we evaluated SNPs in the , , , , and loci from 25,195 older Taiwanese individuals from the Taiwan Biobank. Mini-Mental State Examination (MMSE) was scrutinized for all participants, where MMSE scores were employed to evaluate cognitive functions. From our analysis, we identified three novel genes for cognitive aging that have not previously been reported: on chromosome 3 and and on chromosome 11. and are strong candidates for having a role in cognitive aging with mutations in resulting in intellectual disability, and previously found to be associated with associative memory in humans. Additionally, we found the effects of interplays between physical activity and these three novel genes. Our study suggests that genetic variants in the dopamine receptor-related loci may influence cognitive aging individually and by means of gene-physical activity interactions.
多巴胺受体相关基因座与认知功能和神经退行性疾病有关。目前尚不清楚多巴胺受体相关基因座中的遗传变异，如单核苷酸多态性（SNPs），是否可以独立于老年人的复杂相互作用，对认知衰老做出贡献。为了评估多巴胺受体相关基因座中的 SNPs 是否与老年人群的认知衰老有关，我们评估了来自台湾生物银行的 25195 名台湾老年人中多巴胺受体相关基因座中的 SNPs。对所有参与者进行了简易精神状态检查（MMSE），并使用 MMSE 评分评估认知功能。通过我们的分析，我们确定了三个以前未报道过的与认知衰老相关的新基因：位于 3 号染色体上的 和位于 11 号染色体上的 和 。 是认知衰老的候选基因，其突变导致智力障碍， 先前发现与人的联想记忆有关。此外，我们还发现了这些三个新基因与体力活动之间相互作用的影响。我们的研究表明，多巴胺受体相关基因座中的遗传变异可能单独影响认知衰老，也可能通过基因-体力活动相互作用来影响。
