儿童白血病和干细胞移植中的草绿色链球菌：发热性中性粒细胞减少症中经验性万古霉素的风险分层指南综述。
Viridans Group Streptococci in Pediatric Leukemia and Stem Cell Transplant: Review of a Risk-stratified Guideline for Empiric Vancomycin in Febrile Neutropenia.
机构信息
From the Department of Paediatric and Adolescent Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital.
Infectious Diseases Department, Perth Children's Hospital, Perth, Western Australia.
出版信息
Pediatr Infect Dis J. 2021 Sep 1;40(9):832-834. doi: 10.1097/INF.0000000000003210.
Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.
草绿色链球菌（VGS）是免疫抑制儿童败血症的重要原因。我们回顾了在 107 名白血病或接受同种异体移植的儿童中，根据风险分层添加万古霉素对经验性发热性中性粒细胞减少症治疗的有效性。在 19 例 VGS 菌血症发作中，78.9%对风险分层抗生素敏感，包括高危患者的 100%。所有血培养物均在 24 小时内标记为阳性。
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