School of Chemistry and Chemical Engineering, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Huazhong University of Science and Technology, Wuhan 430074, China.
Biomater Sci. 2021 Sep 7;9(17):5897-5906. doi: 10.1039/d1bm00720c. Epub 2021 Jul 21.
Multifunctional nanocomposites have drawn great attention in clinical applications because of their ability to integrate diagnostic and therapeutic functions. Manganese dioxide (MnO), owing to its biocompatibility and magnetic resonance imaging (MRI) properties, has been widely applied in biomedical research. Our previous work on biogenic MnO nanoparticles (Bio-MnO NPs) revealed that intrinsic photothermal properties and stimuli-responsive MRI imaging are particularly promising for the development of theranostic systems. However, further improvement in the photothermal therapy (PTT) performance of Bio-MnO NPs is still required. Herein, we have improved the PTT efficiency of Bio-MnO NPs by in situ synthesis of fluorescent polydopamine (PDA) while generating additional stimuli responsive fluorescence properties in this system, thus further broadening the scope of their theranostic functions. These synthesis conditions are mild and green. The fluorescence of PDA was quenched by capping Bio-MnO NPs and could be recovered upon degradation of Bio-MnO NPs inside tumour cells. Additionally, Mn released from the nanoparticles can support T-weighted MR imaging. Compared to the Bio-MnO NPs alone, the integration of Bio-MnO NPs and PDA significantly enhances the photothermal performance in vitro and in vivo. With their high biocompatibility, these multifunctional composite nanodevices hold great potential for fluorescence imaging and MRI-guided photothermal therapy.
多功能纳米复合材料因其兼具诊断和治疗功能而受到临床应用的广泛关注。二氧化锰（MnO）由于其生物相容性和磁共振成像（MRI）特性，已广泛应用于生物医学研究。我们之前关于生物合成的 MnO 纳米颗粒（Bio-MnO NPs）的研究表明，固有光热特性和响应性 MRI 成像是开发治疗系统的特别有前途的方法。然而，仍需要进一步提高 Bio-MnO NPs 的光热治疗（PTT）性能。在此，我们通过在原位合成荧光聚多巴胺（PDA）的同时提高了 Bio-MnO NPs 的 PTT 效率，从而在该系统中产生了额外的响应性荧光特性，进一步拓宽了它们的治疗功能范围。这些合成条件温和且环保。PDA 的荧光通过包覆 Bio-MnO NPs 而被猝灭，并且可以在肿瘤细胞内的 Bio-MnO NPs 降解时恢复。此外，从纳米颗粒中释放出的 Mn 可以支持 T 加权磁共振成像。与单独的 Bio-MnO NPs 相比，Bio-MnO NPs 和 PDA 的整合显著提高了体外和体内的光热性能。这些多功能复合纳米器件具有高生物相容性，在荧光成像和 MRI 引导的光热治疗方面具有很大的应用潜力。
