Department of Pathology, Liaocheng People's Hospital, Liaocheng, China.
Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Brain Pathol. 2021 Nov;31(6):e12961. doi: 10.1111/bpa.12961. Epub 2021 Jul 19.
Cranial coronal T1-weighted magnetic resonance imaging with contrast enhancement showed a sellar irregular lesion (Figure A). Hematoxylin and eosin staining showed two different morphologies. The majority of tumor cells had medium-sized to large cells with a high nucleus to cytoplasm ratio, vesicular nuclei with prominent nucleoli, and poor adhesion (Figure B), which revealed positive expression of CD20 by Immunohistochemistry (Figure C). The other component showed abundant cytoplasm, spindle-like to ovoid nucleus and rare mitotic figures (Figure D). These tumor cells were positive for Pit-1 (Figure E) and perinuclear punctated structures immunopositive for CK18 (Figure F).
头颅冠状位 T1 加权增强磁共振成像显示鞍区不规则病变（图 A）。苏木精-伊红染色显示两种不同的形态。大多数肿瘤细胞具有中到大细胞，核质比高，泡状核，核仁明显，黏附性差（图 B），免疫组织化学显示 CD20 阳性（图 C）。另一个成分显示丰富的细胞质，梭形至椭圆形核，罕见有丝分裂象（图 D）。这些肿瘤细胞对 Pit-1（图 E）和核周点状 CK18（图 F）免疫阳性。
