Moschou Aikaterini, Ioannou Petros, Moraitaki Eleni, Stafylaki Dimitra, Maraki Sofia, Samonis George, Kofteridis Diamantis P
Department of Internal Medicine, University Hospital of Heraklion, Heraklion, PC 71110 Crete, Greece.
Department of Clinical Microbiology, University Hospital of Heraklion, PC 71110 Crete, Greece.
Trop Med Infect Dis. 2021 Jul 5;6(3):123. doi: 10.3390/tropicalmed6030123.
(1) Background: In an area with a high prevalence of multi-drug resistant Gram-negative bacteria (MDR-GNB), we investigated the colonization of nursing home residents by such organisms. (2) Methods: A point prevalence study was performed in six nursing homes of the Heraklion area on the island of Crete. A rectal swab was taken and cultured from each participant, while additional risk factors such as recent hospitalization or antimicrobial usage were recorded and evaluated. (3) Results: A total of 137 nursing home residents were included in the study. Their mean age was 82.1 years and 19.7% were males. In total, cultures yielded 255 GNB; , and were the most common. Among the microorganisms cultured, 17.6% had the extended-spectrum beta-lactamase phenotype, while 18% were MDR. A statistically significant association was found between recent antimicrobial use and colonization by MDR-GNB; (4) Conclusions: Colonization by MDR-GNB was found to be highly prevalent in nursing home residents. Recent antimicrobial use was associated with MDR-GNB carriage.
(1)背景:在多重耐药革兰氏阴性菌(MDR - GNB)高流行地区,我们调查了养老院居民中此类微生物的定植情况。(2)方法:在克里特岛伊拉克利翁地区的六家养老院进行了一项现患率研究。从每位参与者采集直肠拭子并进行培养,同时记录并评估近期住院或使用抗菌药物等其他危险因素。(3)结果:该研究共纳入137名养老院居民。他们的平均年龄为82.1岁,男性占19.7%。培养物总共产生了255株革兰氏阴性菌; 、 和 是最常见的。在培养的微生物中,17.6%具有超广谱β - 内酰胺酶表型,而18%为多重耐药菌。发现近期使用抗菌药物与多重耐药革兰氏阴性菌定植之间存在统计学显著关联;(4)结论:发现多重耐药革兰氏阴性菌在养老院居民中定植非常普遍。近期使用抗菌药物与多重耐药革兰氏阴性菌携带有关。