Sánchez-Ávila Ronald M, Uribe-Badillo Edmar, Fernández-Vega González Carlos, Muruzabal Francisco, de la Sen-Corcuera Borja, Baamonde Begoña, Quirós Luis M, Anitua Eduardo, Merayo-Lloves Jesús
Fernández-Vega University Institute, Ophthalmology Research Foundation, University of Oviedo, 33071 Oviedo, Spain.
Biotechnology Institute (BTI), 01007 Vitoria, Spain.
Vision (Basel). 2021 Jul 2;5(3):34. doi: 10.3390/vision5030034.
This study aimed to investigate the use of Plasma Rich in Growth Factors (PRGF) associated with tissue ReGeneraTing Agent (RGTA) drops for the treatment of noninfectious corneal ulcers. RGTA treatment was applied (one drop every two days); however, if ulcer closure was not achieved, PRGF eye drops treatment was added (four times/day). The time taken to reach the ulcer closure, the Best Corrected Visual Acuity (BCVA), intraocular pressure (IOP), Visual Analog Scale (VAS, in terms of frequency and severity of symptoms), and Ocular Surface Disease Index (OSDI) were evaluated. Seventy-four patients (79 eyes) were included, and the mean age was 56.8 ± 17.3 years. The neurotrophic corneal ulcer was the most frequent disorder ( = 27, 34.2%), mainly for herpes virus ( = 15, 19.0%). The time of PRGF eye drops treatment associated with the RGTA matrix was 4.2 ± 2.2 (1.5-9.0) months, and the follow-up period was 44.9 ± 31.5 months. The ulcer closure was achieved in 76 eyes (96.2%). BCVA, VAS and OSDI improved from the baseline ( < 0.001), and IOP remained unchanged ( = 0.665). RGTA and PRGF in noninfectious ulcers were effective and could be a therapeutic alternative for this type of corneal disease.
本研究旨在探讨富含生长因子的血浆（PRGF）联合组织再生剂（RGTA）滴眼液治疗非感染性角膜溃疡的效果。采用RGTA治疗（每两天一滴）；然而，若未实现溃疡闭合，则加用PRGF滴眼液治疗（每天四次）。评估达到溃疡闭合所需时间、最佳矫正视力（BCVA）、眼压（IOP）、视觉模拟评分（VAS，根据症状的频率和严重程度）以及眼表疾病指数（OSDI）。纳入74例患者（79只眼），平均年龄为56.8±17.3岁。神经营养性角膜溃疡是最常见的疾病（n = 27，34.2%），主要由疱疹病毒引起（n = 15，19.0%）。与RGTA基质联合使用PRGF滴眼液的治疗时间为4.2±2.2（1.5 - 9.0）个月，随访期为44.9±31.5个月。76只眼（96.2%）实现了溃疡闭合。BCVA、VAS和OSDI较基线有所改善（P < 0.001），而IOP保持不变（P = 0.665）。RGTA和PRGF用于非感染性溃疡有效，可为这类角膜疾病提供一种治疗选择。
