Division of Neurology, Department of Medicine, Jichi Medical University, Yakushiji 3311-1, Shimotsuke, Tochigi, 329-0498, Japan.
Neurol Sci. 2022 Feb;43(2):1079-1086. doi: 10.1007/s10072-021-05465-y. Epub 2021 Jul 21.
Although the relationship between amyotrophic lateral sclerosis (ALS) and cervical spondylotic myelopathy (CSM) is important, data relating to CSM complications in ALS remain lacking.
We aimed to investigate and validate the spinal cord conditions of ALS patients.
We recruited all patients diagnosed with ALS, Parkinson's disease (PD), or chronic inflammatory demyelinating polyneuropathy (CIDP) who were admitted to our department from April 1, 2017, to March 31, 2020. We analyzed the cervical or thoracolumbar magnetic resonance imaging (MRI) scans of these 128 patients. Data relating to spondylosis, cord compression, spinal canal diameter, spinal cord diameter, and the closest distance between the cervical spinal canal and cord were validated using MRI.
Of the 128 patients, 52 had ALS, 48 had PD, and 28 had CIDP. The proportions of both cervical spondylosis and cervical cord compression were highest in the ALS group compared with the other patient groups (p < 0.05). The proportion of cervical spondylosis in ALS patients reached 38.3%, and that of cervical cord compression reached 53.2%. The closest distance between the cervical spinal canal and cord was also significantly smaller in ALS patients compared with CIDP patients (p < 0.05). In contrast to the cervical cord findings, there were no significant differences in the thoracolumbar cord between ALS patients and the other patient groups.
Of the three disease groups, the proportion of CSM was highest in ALS patients. Furthermore, cervical cord conditions were significantly more crowded in the ALS patients than in the other patient groups.
肌萎缩侧索硬化症（ALS）与颈椎病（CSM）之间的关系很重要，但有关 ALS 患者 CSM 并发症的数据仍然缺乏。
本研究旨在探讨和验证 ALS 患者的脊髓状况。
我们招募了所有 2017 年 4 月 1 日至 2020 年 3 月 31 日期间在我院就诊的 ALS、帕金森病（PD）或慢性炎症性脱髓鞘性多发性神经病（CIDP）患者。我们分析了这 128 例患者的颈椎或胸腰椎磁共振成像（MRI）扫描。使用 MRI 对颈椎病、脊髓压迫、椎管直径、脊髓直径以及颈椎管与脊髓的最近距离进行了验证。
128 例患者中，52 例为 ALS 患者，48 例为 PD 患者，28 例为 CIDP 患者。与其他患者组相比，ALS 组的颈椎病变和颈椎脊髓压迫的比例均最高（p<0.05）。ALS 患者颈椎病的比例达到 38.3%，脊髓压迫的比例达到 53.2%。ALS 患者颈椎管与脊髓的最近距离也明显小于 CIDP 患者（p<0.05）。与颈椎脊髓相比，ALS 患者与其他患者组之间的胸腰椎脊髓无显著差异。
在这三组疾病中，CSM 在 ALS 患者中比例最高。此外，ALS 患者的颈髓状况明显比其他患者拥挤。
