塞来昔布引起的药物热：一例罕见病例报告及文献综述。
Celecoxib-induced drug fever: A rare case report and literature review.
作者信息
Xiao Jing, Jia Su-Jie, Wu Cui-Fang
机构信息
Department of Pharmacy, The Third Xiangya Hospital of Central South University, Changsha, China.
Department of Pharmacy, Ji'an Hospital of Shanghai East Hospital, Ji'an, China.
出版信息
J Clin Pharm Ther. 2022 Mar;47(3):402-406. doi: 10.1111/jcpt.13490. Epub 2021 Jul 20.
WHAT IS KNOWN AND OBJECTIVE
Drug fever is frequently misdiagnosed, especially during concurrent infection. Celecoxib causes various adverse effects; however, celecoxib-induced drug fever is rarely reported.
CASE SUMMARY
A 32-year-old man presented with pyrexia after 17 days of celecoxib therapy, which was reintroduced following 3-day total drug cessation. His fever recurred after this unsuspected rechallenge, which aided in the ultimate identification of the offending drug. A Naranjo Score of 8 led us to infer that drug fever was "probably" caused by celecoxib.
WHAT IS NEW AND CONCLUSION
This is the first report of celecoxib-induced drug fever, aimed at assisting its diagnosis, particularly with rarely suspected causative drugs.
已知信息与目的
药物热常被误诊，尤其是在合并感染时。塞来昔布会引起多种不良反应；然而，塞来昔布诱发的药物热鲜有报道。
病例摘要
一名32岁男性在接受塞来昔布治疗17天后出现发热，在停药3天后重新使用该药。在这次意外的再次用药后发热复发，这有助于最终确定致病药物。纳伦霍评分8分使我们推断药物热“可能”是由塞来昔布引起的。
新发现与结论
这是塞来昔布诱发药物热的首例报道，旨在辅助其诊断，尤其是对于罕见可疑致病药物的情况。
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