Department of Plant Molecular Biology, Biophore Building, University of Lausanne, Lausanne, Switzerland.
Institute of Cytology and Genetics, Novosibirsk, Russian Federation.
FEBS J. 2022 Oct;289(20):6172-6186. doi: 10.1111/febs.16132. Epub 2021 Aug 3.
A small family composed of BRI1 KINASE INHIBITOR1 (BKI1) and MEMBRANE-ASSOCIATED KINASE REGULATORS (MAKRs) has recently captured the attention of plant biologists, due to their involvement in developmental processes downstream of hormones and Receptor-Like Kinases (RLK) signalling. BKI1/MAKRs are intrinsically disordered proteins (so-called unstructured proteins) and as such lack specific domains. Instead, they are defined by the presence of two conserved linear motifs involved in the interaction with lipids and proteins, respectively. Here, we first relate the discovery of the MAKR gene family. Then, we review the individual function of characterized family members and discuss their shared and specific modes of action. Finally, we explore and summarize the structural, comparative and functional genomics data available on this gene family. Together, this review aims at building a comprehensive reference about BKI1/MAKR protein function in plants.
一个由 BRI1 激酶抑制剂 1（BKI1）和膜相关激酶调节剂（MAKRs）组成的小家族，由于它们参与激素和受体样激酶（RLK）信号下游的发育过程，最近引起了植物生物学家的关注。BKI1/MAKRs 是无规则的内在蛋白（所谓的无结构蛋白），因此缺乏特定的结构域。相反，它们分别由两个保守的线性基序的存在来定义，这些基序分别涉及与脂质和蛋白质的相互作用。在这里，我们首先介绍 MAKR 基因家族的发现。然后，我们回顾了已鉴定的家族成员的个体功能，并讨论了它们的共同和特定作用模式。最后，我们探索并总结了这个基因家族的结构、比较和功能基因组学数据。总的来说，这篇综述旨在建立一个关于植物中 BKI1/MAKR 蛋白功能的综合参考。
