Department of Urology, Nara Medical University, Kashihara, Japan.
Department of Prostate Brachytherapy, Nara Medical University, Kashihara, Japan.
Low Urin Tract Symptoms. 2022 Jan;14(1):4-9. doi: 10.1111/luts.12402. Epub 2021 Jul 20.
Lower urinary tract symptoms are transiently exacerbated by low-dose-rate brachytherapy (LDR-BT) for prostate cancer and recover to pretreatment levels 1 year thereafter. Generally, these symptoms are influenced by temperature. We aimed to search for factors affecting the lower urinary tract symptoms after seed implant including seasons.
We retrospectively enrolled 812 patients who underwent LDR-BT at Nara Medical University Hospital from January 2010 to December 2018 and for whom the International Prostate Symptom Score, Overactive Bladder Symptom Score, and frequency volume charts were available. We investigated the relationships between lower urinary tract symptoms, 24-hours urinary frequency, 24-hours urinary volume before and after seed implant, radiation dose, and season of seed implant.
The mean age was 69.5 years. The mean prostate volume was 24.2 mL. The International Prostate Symptom Score, Overactive Bladder Symptom Score, and 24-hours urinary frequency increased until 3 months and gradually decreased over 6 months after seed implant. Multiple linear regression analysis revealed that 24-hours urinary frequency at 3 months after seed implant was significantly influenced by external beam radiotherapy, larger prostate volume before implant, higher 24-hours urinary frequency at baseline, larger 24-hours urinary volume at 3 months after implant, and performance of implant in summer.
Lower urinary tract symptoms worsened 3 months after seed implant of LDR-BT regardless of the season of implant. The urinary frequency 3 months after seed implant was slightly lower when seed implant was performed in the summer.
低剂量率近距离放射治疗（LDR-BT）治疗前列腺癌后，下尿路症状会短暂加重，并在 1 年后恢复到治疗前水平。一般来说，这些症状受温度影响。我们旨在寻找影响种子植入后下尿路症状的因素，包括季节。
我们回顾性纳入了 2010 年 1 月至 2018 年 12 月期间在奈良医科大学医院接受 LDR-BT 的 812 例患者，这些患者的国际前列腺症状评分、膀胱过度活动症症状评分和频数-尿量图表可用。我们调查了下尿路症状、植入前后 24 小时尿频数、24 小时尿量、辐射剂量与种子植入季节之间的关系。
平均年龄为 69.5 岁。平均前列腺体积为 24.2 毫升。国际前列腺症状评分、膀胱过度活动症症状评分和 24 小时尿频数在植入后 3 个月内持续增加，6 个月后逐渐下降。多元线性回归分析显示，植入后 3 个月时的 24 小时尿频数受外照射放疗、植入前较大的前列腺体积、基线时较高的 24 小时尿频数、植入后 3 个月时较大的 24 小时尿量以及夏季进行植入术的影响。
LDR-BT 种子植入后无论植入季节如何，下尿路症状都会在 3 个月时加重。夏季进行种子植入时，植入后 3 个月时的尿频数会略有降低。
