前扣带回皮层中的催产素通过抑制突触前长时程增强来减轻神经性疼痛和情绪焦虑。

Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation.

作者信息

Li Xu-Hui, Matsuura Takanori, Xue Man, Chen Qi-Yu, Liu Ren-Hao, Lu Jing-Shan, Shi Wantong, Fan Kexin, Zhou Zhaoxiang, Miao Zhuang, Yang Jiale, Wei Sara, Wei Feng, Chen Tao, Zhuo Min

机构信息

Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Institute of Brain Research, Qingdao International Academician Park, Qingdao, Shandong, China.

Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Orthopaedics, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

出版信息

Cell Rep. 2021 Jul 20;36(3):109411. doi: 10.1016/j.celrep.2021.109411.

DOI:10.1016/j.celrep.2021.109411

PMID:34289348

Abstract

Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and post-LTP contribute to chronic-pain-related anxiety and behavioral sensitization. The roles of oxytocin in the ACC have not been studied. Here, we find that microinjections of oxytocin into the ACC attenuate nociceptive responses and anxiety-like behavioral responses in animals with neuropathic pain. Application of oxytocin selectively blocks the maintenance of pre-LTP but not post-LTP. In addition, oxytocin enhances inhibitory transmission and excites ACC interneurons. Similar results are obtained by using selective optical stimulation of oxytocin-containing projecting terminals in the ACC in animals with neuropathic pain. Our results demonstrate that oxytocin acts on central synapses and reduces chronic-pain-induced anxiety by reducing pre-LTP.

摘要

催产素是一种著名的神经垂体激素，在行为焦虑和痛觉感受中发挥重要作用。在扣带回前部皮质（ACC）中已鉴定出两种主要形式的长时程增强，即突触前长时程增强（pre-LTP）和突触后长时程增强（post-LTP）。pre-LTP和post-LTP均与慢性疼痛相关的焦虑和行为敏化有关。催产素在ACC中的作用尚未得到研究。在此，我们发现向ACC中微量注射催产素可减弱神经性疼痛动物的伤害性反应和焦虑样行为反应。催产素的应用选择性地阻断了pre-LTP的维持，但不影响post-LTP。此外，催产素增强抑制性传递并兴奋ACC中间神经元。在神经性疼痛动物中，通过对ACC中含催产素的投射终末进行选择性光刺激也获得了类似结果。我们的结果表明，催产素作用于中枢突触，并通过减少pre-LTP来减轻慢性疼痛引起的焦虑。