一大群镰状细胞贫血儿童中的新型肾损伤生物标志物
Novel kidney injury biomarkers in a large cohort of children with sickle cell anemia.
作者信息
Belisário André R, S Filha Roberta da, de Almeida Jéssica A, Mendes Fabíola G, Rezende Paulo V, Vieira Érica Lm, E Silva Ana Cs
机构信息
Centro de Tecidos Biológicos de Minas Gerais, Fundação Hemominas, Lagoa Santa, Minas Gerais, 33400000, Brazil.
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, 30130100, Brazil.
出版信息
Biomark Med. 2021 Aug;15(12):999-1009. doi: 10.2217/bmm-2020-0769. Epub 2021 Jul 22.
The aim of this study was to compare novel kidney injury biomarkers in sickle cell anemia (SCA) children with and without albuminuria or glomerular hyperfiltration. A total of 358 Brazilian children with SCA were studied. Fifteen kidney injury biomarkers in urine were measured. Albuminuria was defined as urine albumin/creatinine ratio >100 mg/g. Glomerular hyperfiltration was defined as estimated glomerular filtration rate ≥140 ml/min/1.73 m. After adjustment for age, sex and modifying therapies in use, EGF and collagen IV urinary levels were associated with albuminuria. Renin and clusterin levels were associated with hyperfiltration. Levels of novel kidney injury biomarkers were associated with albuminuria and hyperfiltration in Brazilian children with SCA, suggesting concomitant structural and functional abnormalities.
本研究的目的是比较患有和未患有蛋白尿或肾小球超滤的镰状细胞贫血（SCA）儿童的新型肾损伤生物标志物。共研究了358名巴西SCA儿童。检测了尿液中的15种肾损伤生物标志物。蛋白尿定义为尿白蛋白/肌酐比值>100 mg/g。肾小球超滤定义为估计肾小球滤过率≥140 ml/min/1.73 m²。在对年龄、性别和正在使用的改良疗法进行调整后，尿液中表皮生长因子（EGF）和IV型胶原水平与蛋白尿相关。肾素和簇集蛋白水平与超滤相关。新型肾损伤生物标志物水平与巴西SCA儿童的蛋白尿和超滤相关，提示存在结构和功能异常。
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