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原发性胸膜鳞状细胞癌,PD-L1高度阳性,对卡瑞利珠单抗显示出显著反应:一例报告

Primary Pleural Squamous Cell Carcinoma, Highly Positive PD-L1, Shows Marked Response to Camrelizumab: A Case Report.

作者信息

Wang Yao, Gao Ying, Chen Hai-Ruo, Liu Hong, Fu Xi, Yan Ran, You Feng-Ming, Li Zhuo-Hong

机构信息

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

出版信息

Clin Med Insights Oncol. 2021 Jul 12;15:11795549211028571. doi: 10.1177/11795549211028571. eCollection 2021.

Abstract

Here, we reported the rare case of primary pleural squamous cell carcinoma (PPSCC) in a 71-year-old male patient. After chemo and targeted therapies, the patient showed continuous tumor progression and clinical deterioration. Fortunately, the patient had a high expression level of PD-L1 (80%) in the tumor tissues. Ultimately, the patient survived for additional 6 months with camrelizumab treatment. In summary, camrelizumab may be a good candidate for the treatment of PPSCC, especially in tumors with high PD-L1 expression.

摘要

在此,我们报告了一例71岁男性原发性胸膜鳞状细胞癌(PPSCC)的罕见病例。经过化疗和靶向治疗后,患者肿瘤持续进展,临床症状恶化。幸运的是,患者肿瘤组织中PD-L1表达水平较高(80%)。最终,患者接受卡瑞利珠单抗治疗后又存活了6个月。总之,卡瑞利珠单抗可能是治疗PPSCC的良好选择,尤其是对于PD-L1高表达的肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c58/8278452/fba25830aff6/10.1177_11795549211028571-fig1.jpg

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