高压氧联合艾司西酞普兰治疗抑郁症的疗效及其对认知功能的影响。
Efficacy of hyperbaric oxygen combined with escitalopram in depression and its effect on cognitive function.
作者信息
Mi Kun, Guo Qiang, Xu Bao-Yan, Wang Man, Bi Hao
机构信息
Kun Mi, The Second Department of Affective Disorders, The Sixth People's Hospital of Hebei Province, Baoding, Hebei, 071000, P.R. China.
Qiang Guo, Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
出版信息
Pak J Med Sci. 2021 Jul-Aug;37(4):1054-1057. doi: 10.12669/pjms.37.4.3993.
OBJECTIVE
To investigate the efficacy of hyperbaric oxygen (HBO) combined with escitalopram in patients with depression and its effect on cognitive function.
METHODS
From 2016 to 2018, seventy patients with depression aged 18-65 years treated in Affiliated Hospital of Hebei University were selected. Seventy patients with depression meeting the diagnostic criteria of ICD-10 were selected and randomly divided into control group and observation group using a random number table, with 35 patients in each group. The control group was treated with escitalopram, while the observation group was additionally treated with HBO on this basis. The patients were assessed using the Hamilton Depression Scale (HAMD) and Montreal Cognitive Assessment Scale (MoCA) before treatment and two, four and six weeks after treatment.
RESULTS
Two weeks after treatment, HAMD score showed a statistically significant difference between the two groups ( < 0.05). No statistically significant differences were found in HAMD score between the two groups four and six weeks after treatment ( > 0.05). Four and six weeks after treatment, MoCA score presented statistically significant differences between the two groups ( < 0.05).
CONCLUSION
Escitalopram combined with HBO in the treatment of depression presents rapid efficacy and a certain effect in improving cognitive function.
目的
探讨高压氧（HBO）联合艾司西酞普兰治疗抑郁症患者的疗效及其对认知功能的影响。
方法
选取2016年至2018年在河北大学附属医院治疗的18 - 65岁抑郁症患者70例。选取70例符合ICD - 10诊断标准的抑郁症患者，采用随机数字表法随机分为对照组和观察组，每组35例。对照组采用艾司西酞普兰治疗，观察组在此基础上联合HBO治疗。治疗前及治疗后2周、4周、6周采用汉密尔顿抑郁量表（HAMD）和蒙特利尔认知评估量表（MoCA）对患者进行评估。
结果
治疗2周后，两组HAMD评分差异有统计学意义（<0.05）。治疗4周和6周后，两组HAMD评分差异无统计学意义（>0.05）。治疗4周和6周后，两组MoCA评分差异有统计学意义（<0.05）。
结论
艾司西酞普兰联合HBO治疗抑郁症起效快，对改善认知功能有一定作用。
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