Yoshimura Reiji, Ikenouchi Atsuko, Okamoto Naomichi, Konishi Yuki
Psychiatry, University of Occupational and Environmental Health, Kitakyushu, JPN.
Cureus. 2021 Jun 18;13(6):e15750. doi: 10.7759/cureus.15750. eCollection 2021 Jun.
We report the case of a 67-year-old Japanese Parkinson's disease (PD) patient with depression who was successfully treated with vortioxetine. The patient's PD was being treated with levodopa (100 mg/day). As improvement was noted in PD symptoms, levodopa was continued. Subsequently, she was referred to our department due to worsening of her depressive symptoms, including depressed mood, anhedonia, decreased energy, decreased concentration, decreased motivation, insomnia, hopelessness, and worthlessness. The patient did not respond to paroxetine and escitalopram. Finally, vortioxetine improved her depressive state without worsening PD.
我们报告了一例67岁患有抑郁症的日本帕金森病（PD）患者，其使用伏硫西汀治疗成功。该患者的帕金森病正在接受左旋多巴（100毫克/天）治疗。由于帕金森病症状有所改善，左旋多巴持续使用。随后，她因抑郁症状恶化，包括情绪低落、快感缺失、精力下降、注意力不集中、动力减退、失眠、绝望和无价值感，被转诊至我科。该患者对帕罗西汀和艾司西酞普兰无反应。最后，伏硫西汀改善了她的抑郁状态，且未使帕金森病恶化。
