Banderali Umberto, Leanza Luigi, Eskandari Najmeh, Gentile Saverio
Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada.
Department of Biology, University of Padova, Padova, Italy.
Rev Physiol Biochem Pharmacol. 2022;183:135-155. doi: 10.1007/112_2021_62.
Cancer is a collection of diseases caused by specific changes at the genomic level that support cell proliferation indefinitely. Traditionally, ion channels are known to control a variety of cellular processes including electrical signal generation and transmission, secretion, and contraction by controlling ionic gradients. However, recent studies had brought to light important facts on ion channels in cancer biology.In this review we discuss the mechanism linking potassium or chloride ion channel activity to biochemical pathways controlling proliferation in cancer cells and the potential advantages of targeting ion channels as an anticancer therapeutic option.
癌症是由基因组水平的特定变化引起的一系列疾病，这些变化支持细胞无限增殖。传统上，人们已知离子通道通过控制离子梯度来控制多种细胞过程，包括电信号的产生和传导、分泌以及收缩。然而，最近的研究揭示了癌症生物学中离子通道的重要事实。在本综述中，我们讨论了将钾离子或氯离子通道活性与控制癌细胞增殖的生化途径联系起来的机制，以及将离子通道作为抗癌治疗选择的潜在优势。
