Reusz G S, Tulassay T, Szabò A, Miltényi M
1st Department of Pediatrics, Semmelweis University, Medical School, Budapest, Hungary.
Int J Pediatr Nephrol. 1987 Jul-Sep;8(3):147-51.
The effect of short term hydrochlorothiazide therapy on urinary calcium excretion was compared to that of low calcium and a combined low calcium and low sodium diet in 30 children with postglomerular hematuria. On basal conditions 9 children were normocalciuric, 11 had absorptive, 10 renal hypercalciuria. The effect of thiazide treatment on the haematuria was also evaluated. Thiazide revealed to be more effective in reducing calcium excretion than low calcium diet alone in all groups (p less than 0.001 in normocalciuria; p less than 0.01 in both hypercalciuric groups). Combined low calcium--low sodium diet and thiazide treatment were equally effective in reducing calcium excretion in the hypercalciuric groups. On the first 3 days of thiazide treatment a slight increase of hematuria was observed; in the following period a significant decrease in the occurrence (p less than 0.01 in both hypercalciuric groups) and degree (p less than 0.01 in absorptive; p less than 0.02 in renal hypercalciuria) of hematuria was noted. These data furnish further evidence on the relation of hypercalciuria and post-glomerular hematuria.
在30名肾小球后性血尿患儿中，比较了短期氢氯噻嗪治疗对尿钙排泄的影响与低钙饮食以及低钙和低钠联合饮食的影响。在基础条件下，9名儿童尿钙正常，11名有吸收性高钙尿，10名有肾性高钙尿。还评估了噻嗪类药物治疗对血尿的影响。在所有组中，噻嗪类药物在减少钙排泄方面比单独的低钙饮食更有效（尿钙正常组中p<0.001；两个高钙尿组中p<0.01）。在高钙尿组中，低钙-低钠联合饮食和噻嗪类药物治疗在减少钙排泄方面同样有效。在噻嗪类药物治疗的前3天，观察到血尿略有增加；在随后的时期，血尿的发生率（两个高钙尿组中p<0.01）和程度（吸收性高钙尿中p<0.01；肾性高钙尿中p<0.02）均显著降低。这些数据为高钙尿与肾小球后性血尿之间的关系提供了进一步的证据。
