DYRK1B 基因表达研究及其与埃及小样本队列代谢综合征的相关性。
Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
机构信息
Faculty of Biotechnology, October University for Modern Sciences and Arts University (MSA), No. 12567, 54 Anwar El-Sadat street, Al-Haram, Giza, Egypt.
Faculty of Science, Chemistry Department, Cairo University, Giza, Egypt.
出版信息
Mol Biol Rep. 2021 Jul;48(7):5497-5502. doi: 10.1007/s11033-021-06560-1. Epub 2021 Jul 21.
BACKGROUND
A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian.
MATERIALS AND METHODS
A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR.
RESULTS
We observed marked overexpression in DYRK1B (p < 0.05) in MetS subjects when compared with the healthy control subjects.
CONCLUSION
This is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.
背景
许多 2 型糖尿病和心血管疾病的风险因素聚集在一起用于描述代谢综合征（MetS）。此外，与代谢综合征相关的遗传差异在其患病率和副作用中起着关键作用。本研究旨在研究埃及小队列中 DYRK1B 的表达及其与代谢综合征的关系。
材料和方法
共纳入 100 名埃及成年人（50 名代谢综合征患者和 50 名健康对照组）进行本研究。评估临床、生化和人体测量分析。使用实时 PCR 比较两组受试者中 DYRK1B 的相对基因表达。
结果
与健康对照组相比，我们观察到代谢综合征患者中 DYRK1B 的表达明显升高（p<0.05）。
结论
这是第一项提供证据表明 DYRK1B 在代谢综合征患者中高度表达的研究。
Zotero 插件