Franz J, Volkert W A, Barefield E K, Holmes R A
Department of Radiology, University of Missouri-Columbia.
Int J Rad Appl Instrum B. 1987;14(6):569-72. doi: 10.1016/0883-2897(87)90027-4.
A bifunctional chelating agent (BFCA) based on a macrocyclic amine, cyclam, was used to form specifically 99mTc labeled rabbit-anti-HSA-antibodies. This study demonstrates the feasibility of forming a highly stable cyclam-based 99mTc-BFCA with its subsequent conjugation to antibodies.
一种基于大环胺环胺的双功能螯合剂（BFCA）被用于特异性地形成99mTc标记的兔抗人血清白蛋白抗体。本研究证明了形成一种高度稳定的基于环胺的99mTc-BFCA并随后将其与抗体偶联的可行性。
